Evidence map›Paper›PMID 29948869›Full record

Trial reportObesity surgery2018

A Randomized, Double-Blind, Placebo-Controlled Trial of Intravenous Acetaminophen on Hospital Length of Stay in Obese Individuals Undergoing Sleeve Gastrectomy.

Farrell E Cooke, Jon D Samuels, Alfons Pomp, Farida Gadalla, Xian Wu, Cheguevara Afaneh, Gregory F Dakin, Peter A Goldstein

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Obesity surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Farrell E CookeDepartment of Anesthesiology, Weill Cornell Medical College, 1300 York Avenue, Room A-1050, New York, NY, 10065, USA.
Jon D SamuelsDepartment of Anesthesiology, Weill Cornell Medical College, 1300 York Avenue, Room A-1050, New York, NY, 10065, USA.
Alfons PompDepartment of Surgery, Weill Cornell Medical College, New York, NY, USA.
Farida GadallaDepartment of Anesthesiology, Weill Cornell Medical College, 1300 York Avenue, Room A-1050, New York, NY, 10065, USA.
Xian WuDepartment of Healthcare Policy and Research (Division of Biostatistics and Epidemiology), Weill Cornell Medical College, New York, NY, USA.
Cheguevara AfanehDepartment of Surgery, Weill Cornell Medical College, New York, NY, USA.
Gregory F DakinDepartment of Surgery, Weill Cornell Medical College, New York, NY, USA.
Peter A GoldsteinDepartment of Anesthesiology, Weill Cornell Medical College, 1300 York Avenue, Room A-1050, New York, NY, 10065, USA. pag2014@med.cornell.edu.
Cornell University · US

Funding

Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
Clinical and Translational Science CenterUL1TR000457 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$46.0M
NCATS NIH HHS UL1 TR000457NCATS NIH HHS UL1 TR002384
6 · The paper itself

Abstract

backgroundRetrospective studies indicate that acetaminophen iv administration reduces hospital length of stay (LoS) and opiate consumption in patients undergoing bariatric surgery.

objectiveThis study sought to determine whether using acetaminophen iv in morbidly obese subjects undergoing sleeve gastrectomy decreased LoS and total hospital charges as compared to patients receiving saline placebo.

settingSingle-center university hospital

methodsUsing a randomized, double-blind, placebo-controlled design, subjects were assigned to receive either acetaminophen iv (group A) or saline placebo iv (group P). Data were collected between Jan 1 and Dec 31, 2016. Group A received acetaminophen every 6 h for a total of four doses. The first dose was administered following the induction of general anesthesia; group P received saline iv on the same schedule. Anesthetic management and prophylactic antiemetic regimen were standardized in all subjects. Postoperative pain management consisted of hydromorphone via patient-controlled infusion pump. Primary outcomes include hospital LoS and associated hospital costs. Secondary outcomes include patient satisfaction and postoperative nausea and pain scores.

resultsSubject demographics (n = 127) and intraoperative management were similar in the two groups. Across all subjects, median hospital LoS in group A (n = 63) was 1.87 vs. 1.97 days in group P (n = 64) (p = 0.03, Wilcoxon rank-sum test). Postoperatively, daily quality-of-recovery (QoR-15) scores, narcotic consumption, and the use of rescue antiemetics were not significantly different between groups. Median hospital costs were as follows: group A, $12,885 vs. group P, $12,977 (n = 64).

conclusionsAcetaminophen iv may reduce hospital LoS in subjects undergoing sleeve gastrectomy.

Indexed as

AcetaminophenAnalgesics, Non-NarcoticAdministration, IntravenousDouble-Blind MethodGastrectomyHumansIntraoperative PeriodLength of StayObesity, MorbidPostoperative PainAcetaminophenAnalgesics, Non-NarcoticAcetaminophenDouble blindObesityPlaceboProspectiveRandomized controlled trialRCTSurgery

Identifiers

PMID29948869
OpenAlexW2806489833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.