ArticleMetabolic brain disease2018
Probiotics decrease depressive behaviors induced by constipation via activating the AKT signaling pathway.
Article in Metabolic brain disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- The microbiota-gut- hippocampus axis.Frontiers in neuroscience · 2022Pooled it
- Cluster analysis of research hotspots and trends in probiotics for constipation: A comprehensive bibliometric analysis (1977-2024).Medicine · 2026Article
- Polydopamine cross-linked Bifidobacterium single cell core-shell system with multi-target regulation to alleviate constipation in mice.Archives of microbiology · 2026Article
- Deciphering the mechanistic involvement of PANoptosis in FC-MDD comorbidity through the gut-brain axis.Frontiers in immunology · 2026Review
- Stable rat models in constipation with depression and anxiety: evaluation and validation.Frontiers in behavioral neuroscience · 2026Article
- The postbiotic of hawthorn-probiotic ameliorates constipation by multi-pathway inhibition of PANoptosis in intestinal epithelial cells.Frontiers in immunology · 2025Article
- Probiotics, gut microbiota, and brain health: Exploring therapeutic pathways.AIMS microbiology · 2025Review
- Exploring Therapeutic Advances: A Comprehensive Review of Intestinal Microbiota Modulators.Antibiotics (Basel, Switzerland) · 2024Review
- Review
- Review
- Arctiin alleviates functional constipation by enhancing intestinal motility in mice.Experimental and therapeutic medicine · 2023Article
- The contribution of probiotics for the double-edge effect of cefazolin on postoperative neurocognitive disorders by rebalancing the gut microbiota.Frontiers in neuroscience · 2023Article
- Development and validation of a dynamic risk prediction system for constipation in patients with amyotrophic lateral sclerosis.Frontiers in neurology · 2022Article
- Immune-microbiome interplay and its implications in neurodegenerative disorders.Metabolic brain disease · 2022Review
- Engineered 5-HT producing gut probiotic improves gastrointestinal motility and behavior disorder.Frontiers in cellular and infection microbiology · 2022Article
- Gut microbiota in ischemic stroke: Where we stand and challenges ahead.Frontiers in nutrition · 2022Review
- The protective effect of Buzhong Yiqi decoction on ischemic stroke mice and the mechanism of gut microbiota.Frontiers in neuroscience · 2022Article
- Marine Natural Products: Promising Candidates in the Modulation of Gut-Brain Axis towards Neuroprotection.Marine drugs · 2021Review
- β-Glucan from Lentinula edodes prevents cognitive impairments in high-fat diet-induced obese mice: involvement of colon-brain axis.Journal of translational medicine · 2021Article
- Integrated Analysis of the Cecal Microbiome and Plasma Metabolomics to Explore NaoMaiTong and Its Potential Role in Changing the Intestinal Flora and Their Metabolites in Ischemic Stroke.Frontiers in pharmacology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic constipation is often accompanied by emotional disorders such as depression and anxiety. The aim of this study was to determine whether administration of a multispecies probiotic can decrease depressive behaviors through the gut-brain axis and identify any underlying mechanisms. A mouse model of constipation induced by loperamide (5 mg·kg
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.