Evidence map›Paper›PMID 29948567›Full record

Observational studyDigestive diseases and sciences2018

Epinephrine Dose Has a Preventive Effect on the Occurrence of Stress Ulcer-Induced Gastrointestinal Bleeding in Critically Ill Patients.

Aymeric Becq, Saik Urien, Maximilien Barret, Christophe Faisy

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Digestive diseases and sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Esmolol inhibits inflammation and apoptosis in the intestinal tissue via the overexpression of NF-κB-p65 in the early stage sepsis rats.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Aymeric BecqDepartment of Gastroenterology and Endoscopy, Saint Antoine Hospital, Assistance Publique - Hôpitaux de Paris, 184 rue du Faubourg Saint Antoine, 75012, Paris, France. Aymeric.becq@aphp.fr.ORCID http://orcid.org/0000-0003-4637-9012
Saik UrienClinical Investigations Center-1419 INSERM, EA7323 - University Paris-Descartes Sorbonne-Paris Cité, Paris, France.
Maximilien BarretDepartment of Gastroenterology, Cochin Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
Christophe FaisyClinical Investigations Center-1419 INSERM, EA7323 - University Paris-Descartes Sorbonne-Paris Cité, Paris, France.
Délégation Paris 5 · FRHôpital Cochin · FRSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpinephrine may impair splanchnic blood flow, but the impact of epinephrine dose on the occurrence of clinically significant gastrointestinal bleeding (CSGB) caused by stress ulcer remains unclear. We investigated the effect of epinephrine dose on the occurrence of stress ulcer-related CSGB in intensive care unit (ICU) patients.

methodsIn this prospective, observational, cohort study conducted in a French teaching hospital, 40 consecutive ICU patients receiving epinephrine infusion in whom a stress ulcer was diagnosed by an upper gastrointestinal endoscopy were included, from February 2010 to July 2015. The effects of epinephrine dose, and other covariates, on the occurrence of stress ulcer-related CSGB were analyzed using a multiple logistic regression model for repeated measures: At each observation, each patient serves as his own control.

resultsA total of 1484 time-dependent epinephrine dose modifications were available for analysis. The median epinephrine dose rate was 0.8 (0-9.5) mg/h, and the median epinephrine cumulative dose was 44.8 (2.6-2343) mg. Epinephrine, expressed as the average dose per day at time t, had a significant protective effect on the occurrence of stress ulcer (odds ratio 0.22; 95% confidence interval (CI), 0.12-0.38; p < 0.0001, for a log10 increase of epinephrine dose). Enteral feeding had also a protective effect (odds ratio 0.55; 95% CI 0.41-0.72; p < 0.0001, for a log10 increase of kcal/day). Only renal replacement therapy increased the occurrence of stress ulcer in the model.

conclusionsAn increase in the average dose of epinephrine per day increased the time to occurrence of stress ulcer in critically ill patients.

Indexed as

Gastrointestinal HemorrhagePeptic UlcerStress, PhysiologicalAgedCritical IllnessDose-Response Relationship, DrugEndoscopy, GastrointestinalEpinephrineFemaleFranceHumansIntensive Care UnitsMaleMiddle AgedProspective StudiesProtective AgentsEpinephrineProtective AgentsVasoconstrictor AgentsCritically ill patientsEnteral nutritionEpinephrine doseGastrointestinal bleedingStress ulcer

Identifiers

PMID29948567
OpenAlexW2808280529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.