Evidence map›Paper›PMID 29948383›Full record

ArticleArchives of virology2018

Genomic characterization of circoviruses associated with acute gastroenteritis in minks in northeastern China.

Junwei Ge, Shanshan Gu, Xingyang Cui, Lili Zhao, Dexing Ma, Yunjia Shi, Yuanzhi Wang, Taofeng Lu, Hongyan Chen

Open access · bronzeAbstract read
In one paragraph

Article in Archives of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Junwei GeCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.ORCID http://orcid.org/0000-0002-2460-1666
Shanshan GuCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Xingyang CuiCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Lili ZhaoLaboratory Animal and Comparative Medicine Unit, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, No. 678 Haping Rd, Harbin, 150069, China.
Dexing MaCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Yunjia ShiCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Yuanzhi WangLaboratory Animal and Comparative Medicine Unit, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, No. 678 Haping Rd, Harbin, 150069, China.
Taofeng LuLaboratory Animal and Comparative Medicine Unit, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, No. 678 Haping Rd, Harbin, 150069, China.
Hongyan ChenLaboratory Animal and Comparative Medicine Unit, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, No. 678 Haping Rd, Harbin, 150069, China. chenhongyan@caas.cn.
Northeast Agricultural University · CNChinese Academy of Agricultural Sciences · CN

Funding

National Natural Science Foundation of China 31101845Natural Science Foundation of Heilongjiang Province LC2015006State Key Laboratory of Veterinary Biotechnology Foundation SKLVBF201611
6 · The paper itself

Abstract

Mink circovirus (MiCV), a virus that was newly discovered in 2013, has been associated with enteric disease. However, its etiological role in acute gastroenteritis is unclear, and its genetic characteristics are poorly described. In this study, the role of circoviruses (CVs) in mink acute gastroenteritis was investigated, and the MiCV genome was molecularly characterized through sequence analysis. Detection results demonstrated that MiCV was the only pathogen found in this infection. MiCVs and previously characterized CVs shared genome organizational features, including the presence of (i) a potential stem-loop/nonanucleotide motif that is considered to be the origin of virus DNA replication; (ii) two major inversely arranged open reading frames encoding putative replication-associated proteins (Rep) and a capsid protein; (iii) direct and inverse repeated sequences within the putative 5' region; and (iv) motifs in Rep. Pairwise comparisons showed that the capsid proteins of MiCV shared the highest amino acid sequence identity with those of porcine CV (PCV) 2 (45.4%) and bat CV (BatCV) 1 (45.4%). The amino acid sequence identity levels of Rep shared by MiCV with BatCV 1 (79.7%) and dog CV (dogCV) (54.5%) were broadly similar to those with starling CV (51.1%) and PCVs (46.5%). Phylogenetic analysis indicated that MiCVs were more closely related to mammalian CVs, such as BatCV, PCV, and dogCV, than to other animal CVs. Among mammalian CVs, MiCV and BatCV 1 were the most closely related. This study could contribute to understanding the potential pathogenicity of MiCV and the evolutionary and pathogenic characteristics of mammalian CVs.

Indexed as

AnimalsCapsid ProteinsChinaCircoviridae InfectionsCircovirusGastroenteritisGenome, ViralGenomicsMinkOpen Reading FramesPhylogenyCapsid Proteins

Identifiers

PMID29948383
PMCPMC7087342
OpenAlexW2808157098

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.