Evidence map›Paper›PMID 29948329›Full record

ArticleMolecular genetics and genomics : MGG2018

Whole mitochondrial genome diversity in two Hungarian populations.

Boris Malyarchuk, Miroslava Derenko, Galina Denisova, Andrey Litvinov, Urszula Rogalla, Katarzyna Skonieczna, Tomasz Grzybowski, Klára Pentelényi, Zsuzsanna Guba, Tamás Zeke and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular genetics and genomics : MGG, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Boris MalyarchukGenetics Laboratory, Institute of Biological Problems of the North, Russian Academy of Sciences, Portovaya Street, 18, Magadan, 685000, Russia. malyarchuk@ibpn.ru.
Miroslava DerenkoGenetics Laboratory, Institute of Biological Problems of the North, Russian Academy of Sciences, Portovaya Street, 18, Magadan, 685000, Russia.
Galina DenisovaGenetics Laboratory, Institute of Biological Problems of the North, Russian Academy of Sciences, Portovaya Street, 18, Magadan, 685000, Russia.
Andrey LitvinovGenetics Laboratory, Institute of Biological Problems of the North, Russian Academy of Sciences, Portovaya Street, 18, Magadan, 685000, Russia.
Urszula RogallaDepartment of Forensic Medicine, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 85-094, Bydgoszcz, Poland.
Katarzyna SkoniecznaDepartment of Forensic Medicine, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 85-094, Bydgoszcz, Poland.
Tomasz GrzybowskiDepartment of Forensic Medicine, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 85-094, Bydgoszcz, Poland.
Klára PentelényiInstitute of Genomic Medicine and Rare Disorders, Semmelweis University, Budapest, 1085, Hungary.
Zsuzsanna GubaHungarian Molecular Anthropological Research Group, Debrecen, 4030, Hungary.
Tamás ZekeHungarian Molecular Anthropological Research Group, Debrecen, 4030, Hungary.
Mária Judit MolnárInstitute of Genomic Medicine and Rare Disorders, Semmelweis University, Budapest, 1085, Hungary.

Funding

Russian Foundation for Basic Research 16-34-00014the Wenner-Gren Foundation ICRG-117
6 · The paper itself

Abstract

Complete mitochondrial genomics is an effective tool for studying the demographic history of human populations, but there is still a deficit of mitogenomic data in European populations. In this paper, we present results of study of variability of 80 complete mitochondrial genomes in two Hungarian populations from eastern part of Hungary (Szeged and Debrecen areas). The genetic diversity of Hungarian mitogenomes is remarkably high, reaching 99.9% in a combined sample. According to the analysis of molecular variance (AMOVA), European populations showed a low, but statistically significant level of between-population differentiation (Fst = 0.61%, p = 0), and two Hungarian populations demonstrate lack of between-population differences. Phylogeographic analysis allowed us to identify 71 different mtDNA sub-clades in Hungarians, sixteen of which are novel. Analysis of ancestry-informative mtDNA sub-clades revealed a complex genetic structure associated with the genetic impact of populations from different parts of Eurasia, though the contribution from European populations is the most pronounced. At least 8% of ancestry-informative haplotypes found in Hungarians demonstrate similarity with East and West Slavic populations (sub-clades H1c23a, H2a1c1, J2b1a6, T2b25a1, U4a2e, K1c1j, and I1a1c), while the influence of Siberian populations is not so noticeable (sub-clades A12a, C4a1a, and probably U4b1a4).

Indexed as

Genetics, PopulationGenetic VariationGenome, MitochondrialHaplotypesDNA, MitochondrialEthnicityHumansHungaryPhylogeographyDNA, MitochondrialComplete mitochondrial genomesGenetic diversityHungariansMolecular phylogeographyPhylogeny

Identifiers

PMID29948329

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.