ArticleJournal of gastroenterology2019
Increase in the skeletal muscle mass to body fat mass ratio predicts the decline in transaminase in patients with nonalcoholic fatty liver disease.
Article in Journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 28 citations in OpenAlex.
- The liver-muscle axis in metabolic dysfunction-associated steatotic liver disease: a narrative review and conceptual framework for body-composition phenotyping.Frontiers in medicine · 2026Review
- Early Liver Function Parameters Predict Independent Walking Ability After Living Donor Liver Transplantation.Medicina (Kaunas, Lithuania) · 2025Article
- Body Composition in Cases with Normal Alanine Aminotransferase Values in Medical Health Checkups.Nutrients · 2024Article
- Glucose metabolism in gestational diabetes and their relationship with fat mass / muscle mass index.European journal of obstetrics & gynecology and reproductive biology: X · 2024Article
- Article
- Serum transthyretin and aminotransferases are associated with lean mass in people with coronary heart disease: Further insights from the CARE-CR study.Frontiers in medicine · 2023Article
- Association of serum creatinine-to-cystatin C ratio with skeletal muscle mass and strength in nonalcoholic fatty liver disease in the Iwaki Health Promotion Project.Journal of clinical biochemistry and nutrition · 2022Article
- Creatinine-to-body weight ratio is a predictor of incident diabetes: a population-based retrospective cohort study.Diabetology & metabolic syndrome · 2022Article
- Relationship between body composition and the histology of non-alcoholic fatty liver disease: a cross-sectional study.BMC gastroenterology · 2021Article
- Comparison of dapagliflozin and teneligliptin in nonalcoholic fatty liver disease patients without type 2 diabetes mellitus: a prospective randomized study.Journal of clinical biochemistry and nutrition · 2021Article
- Serum Creatinine-to-Cystatin C Ratio in the Progression Monitoring of Non-alcoholic Fatty Liver Disease.Frontiers in physiology · 2021Article
- Fat-to-muscle ratio as a predictor of insulin resistance and metabolic syndrome in Korean adults.Journal of cachexia, sarcopenia and muscle · 2020Article
- Creatinine to Body Weight Ratio Is Associated with Incident Diabetes: Population-Based Cohort Study.Journal of clinical medicine · 2020Article
- Effect of Sodium Glucose Co-Transporter 2 Inhibitors on Liver Fat Mass and Body Composition in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus.Clinical drug investigation · 2019Article
- Article
- Sarcopenia definition in patients with NAFLD.Journal of gastroenterology · 2019Article
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13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this retrospective study was to determine the effect of skeletal muscle and body fat on liver function in patients with nonalcoholic fatty liver disease (NAFLD) diagnosed by liver biopsy.
methodsAmong the 219 patients with NAFLD enrolled in this study was a cohort of 139 patients who had their body composition measured with Inbody720 at baseline and at ≥ 1 year postbaseline, to elucidate the relationship between liver function and changes in skeletal muscle and body fat mass. Multivariate analysis was used to identify factors influencing low skeletal muscle mass index (SMI, defined as 7 kg/m
resultsOf the 219 patients enrolled, 27 (12.3%) had a low SMI. Patient age (> 70 years) and female gender were identified as risk factors for low SMI. Hepatic fibrosis was not associated with SMI. In the cohort followed up at baseline and 12 months later, transaminase activity, body fat mass, and SMI significantly decreased over time. Changes in the SF ratio were significantly associated with changes in liver function. An increase in the SF ratio [hazard ratio (HR) 10.99 in men, 6.849 in women] was a predictor of reduced ALT, independent of age and other backgrounds.
conclusionsIn the patients with NAFLD, SMI was decreased, even in the early stages of NAFLD. Therapeutic strategies for NAFLD require a reduction in body fat mass and the maintenance of skeletal muscle is also needed.
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