Evidence map›Paper›PMID 29948230›Full record

ReviewEuropean child & adolescent psychiatry2018

Conduct disorder in adolescent females: current state of research and study design of the FemNAT-CD consortium.

Christine M Freitag, Kerstin Konrad, Christina Stadler, Stephane A De Brito, Arne Popma, Sabine C Herpertz, Beate Herpertz-Dahlmann, Inga Neumann, Meinhard Kieser, Andreas G Chiocchetti and 2 more

Abstract readReview
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In one paragraph

Review in European child & adolescent psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
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  5. Psychoneuroendocrine stress response in female and male youth with major depressive disorder.Journal of child psychology and psychiatry, and allied disciplines · 2025
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  11. Social isolation and aggression training lead to escalated aggression and hypothalamus-pituitary-gonad axis hyperfunction in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 4 countries.

Christine M FreitagDepartment of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital Frankfurt, Goethe University Frankfurt, Deutschordenstraße 50, 60528, Frankfurt am Main, Germany. C.Freitag@em.uni-frankfurt.de.
Kerstin KonradChild Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital RWTH, Aachen, Germany.
Christina StadlerDepartment of Child and Adolescent Psychiatry, University of Basel, Basel, Switzerland.
Stephane A De BritoSchool of Psychology, University of Birmingham, Birmingham, UK.
Arne PopmaDepartment of Child and Adolescent Psychiatry, VUmc/De Bascule, Amsterdam, The Netherlands.
Sabine C HerpertzDepartment of General Psychiatry, Centre of Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Beate Herpertz-DahlmannDepartment of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital RWTH, Aachen, Germany.
Inga NeumannDepartment of Behavioural and Molecular Neurobiology, University of Regensburg, Regensburg, Germany.
Meinhard KieserDepartment of Medical Biometry and Informatics, University Hospital Heidelberg, Heidelberg, Germany.
Andreas G ChiocchettiDepartment of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital Frankfurt, Goethe University Frankfurt, Deutschordenstraße 50, 60528, Frankfurt am Main, Germany.
Christina SchwenckDepartment of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital Frankfurt, Goethe University Frankfurt, Deutschordenstraße 50, 60528, Frankfurt am Main, Germany.
Graeme FairchildDepartment of Psychology, University of Bath, Bath, UK.
RWTH Aachen University · DEUniversity Hospital Frankfurt · DEUniversity Hospital Heidelberg · DEDe Bascule · NLUniversity of Basel · CHUniversity of Bath · GBUniversity of Birmingham · GBUniversity of Giessen · DEUniversity of Regensburg · DE

Funding

European Commission 602407
6 · The paper itself

Abstract

Conduct disorder (CD) is a common and highly impairing psychiatric disorder of childhood and adolescence that frequently leads to poor physical and mental health outcomes in adulthood. The prevalence of CD is substantially higher in males than females, and partly due to this, most research on this condition has used all-male or predominantly male samples. Although the number of females exhibiting CD has increased in recent decades, the majority of studies on neurobiological measures, neurocognitive phenotypes, and treatments for CD have focused on male subjects only, despite strong evidence for sex differences in the aetiology and neurobiology of CD. Here, we selectively review the existing literature on CD and related phenotypes in females, focusing in particular on sex differences in CD symptoms, patterns of psychiatric comorbidity, and callous-unemotional personality traits. We also consider studies investigating the neurobiology of CD in females, with a focus on studies using genetic, structural and functional neuroimaging, psychophysiological, and neuroendocrinological methods. We end the article by providing an overview of the study design of the FemNAT-CD consortium, an interdisciplinary, multi-level and multi-site study that explicitly focuses on CD in females, but which is also investigating sex differences in the causes, developmental course, and neurobiological correlates of CD.

Indexed as

Research DesignAdolescentChildConduct DisorderFemaleHumansYoung AdultAdolescenceAggressionCallous–unemotional traitsConduct disorderFemaleNeurobiologySex differences

Identifiers

PMID29948230
OpenAlexW2806538111

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.