ArticleEuropean journal of nutrition2019
Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study.
Article in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Mediterranean Diet-Based Interventions to Improve Anthropometric and Obesity Indicators in Children and Adolescents: A Systematic Review with Meta-Analysis of Randomized Controlled Trials.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Brazilian Children's Dietary Intake in Relation to Brazil's New Nutrition Guidelines: a Systematic Review.Current nutrition reports · 2019Pooled it
- Effect of antioxidant-rich kindergarten meals on oxidative stress biomarkers in healthy 5-6-year-old children: a randomized controlled trial.European journal of pediatrics · 2024Trial
- Clustering of Unhealthy Diets, Inflammation Levels, and Depressive Symptoms in Chinese Adolescents: A Longitudinal Study.Nutrients · 2026Article
- Interpregnancy interval, air pollution, and the risk of low birth weight: a retrospective study in China.BMC public health · 2024Article
- Joint Exposure to Multiple Air Pollutants, Genetic Susceptibility, and Incident Dementia: A Prospective Analysis in the UK Biobank Cohort.International journal of public health · 2024Article
- Potential Causal Association between Elevated Gamma-Glutamyl Transferase Level and Stroke: A Two-Sample Mendelian Randomization Study.Biomolecules · 2023Article
- Long-Term Air Pollution, Genetic Susceptibility, and the Risk of Depression and Anxiety: A Prospective Study in the UK Biobank Cohort.Environmental health perspectives · 2023Article
- Lack of an association between dietary patterns and adiposity among primary school children in Kilimanjaro Tanzania.BMC nutrition · 2022Article
- Role of Diet Quality in the Association Between Excess Weight and Psychosocial Problems in a Large Sample of Children in Spain.JAMA network open · 2022Article
- The dietary inflammatory index is associated with anti- and pro-inflammatory adipokines in Brazilian schoolchildren.European journal of nutrition · 2021Article
- Joint exposure to various ambient air pollutants and incident heart failure: a prospective analysis in UK Biobank.European heart journal · 2021Article
- Low Adherence to the Mediterranean Diet in Isolated Adolescents: The Mediation Effects of Stress.Nutrients · 2018Article
- A cross-sectional study examining self-reported anthropometric measurements with adolescents' nutrition attitudes, obesity awareness and diet quality indices during the pandemic.Journal of pediatric nursingArticle
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Authors and funding
17 authors at 14 institutions in 9 countries.
Funding
Abstract
aimOur aim is to demonstrate that a healthy diet might reduce the relation between adiposity and inflammation, whereas an unhealthy diet may increase the effect of adiposity on inflammatory biomarkers.
methodsIn 618 adolescents (13-17 years) of the European HELENA study, data were available on body composition, a set of inflammation markers, and food intake determined by a self-administered computerized 24-h recall. A 9-point Mediterranean diet score and an antioxidant-rich diet score were used as dietary parameters and tested as moderator. Total body fat was represented by the sum of six skinfold thicknesses and central adiposity by waist circumference. A set of inflammation-related biomarkers was used as outcome: a pro/anti-inflammatory interleukins ratio, TGFβ-1, C-reactive protein, TNF-α, 3 cell adhesion molecules, and 3 types of immune cells; gamma-glutamyltransferase (GGT) and homocysteine were used as cardiovascular disease risk biomarkers, and alanine transaminase (ALT) as liver dysfunction biomarker. Multiple linear regression analyses tested moderation by diet in the adiposity-inflammation association and were adjusted for age, sex, country, puberty, socioeconomic status.
resultsBoth the Mediterranean and antioxidant-rich diet, and overall and central adiposity, were important in the moderation. Diet was a significant protective moderator in the effect of adiposity on the pro/anti-inflammatory interleukins ratio, TGFβ-1, GGT, and ALT.
conclusionIn conclusion, in some cases, a diet rich in antioxidants and essential nutrients may attenuate the concentration of inflammatory biomarkers caused by adiposity, whereas a poor diet appears to contribute to the onset of early oxidative stress signs.
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