Evidence map›Paper›PMID 29948136›Full record

Trial reportChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2018

Short versus mid-long-term outcome of transanal irrigation in children with spina bifida and anorectal malformations.

Emanuele Ausili, A Marte, G Brisighelli, P Midrio, G Mosiello, E La Pergola, L Lombardi, B D Iacobelli, E Caponcelli, M Meroni and 2 more

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Emanuele AusiliSpina Bifida Center, Department of Science of the Health of Women and Children, Catholic University Medical School, Rome, Italy. emanuele.ausili@tin.it.ORCID 0000-0001-6095-1156
A MartePediatric Surgery Unit, Università della Campania Luigi Vanvitelli, Naples, Italy.
G BrisighelliDepartment of Pediatric Surgery, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy.
P MidrioMother and Child Department, Cà Foncello Regional Hospital, Treviso, Italy.
G MosielloNeuro-Urology Unit/Spina Bifida Center and Department of Medical and Surgical Neonatology, Bambino Gesù Children Hospital and Research Institute, Rome, Italy.
E La PergolaMother and Child Department, Cà Foncello Regional Hospital, Treviso, Italy.
L LombardiPediatric Surgery Unit, Pediatric Hospital, Parma, Italy.
B D IacobelliNeuro-Urology Unit/Spina Bifida Center and Department of Medical and Surgical Neonatology, Bambino Gesù Children Hospital and Research Institute, Rome, Italy.
E CaponcelliPediatric Surgery Unit, Vittore Buzzi Pediatric Hospital, Milan, Italy.
M MeroniPediatric Surgery Unit, Vittore Buzzi Pediatric Hospital, Milan, Italy.
E LevaDepartment of Pediatric Surgery, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy.
C RendeliSpina Bifida Center, Department of Science of the Health of Women and Children, Catholic University Medical School, Rome, Italy.
Bambino Gesù Children's Hospital · ITCa' Foncello Hospital · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITOspedale dei Bambini Vittore Buzzi · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe assessed short- and mid-long-term clinical efficacy of transanal irrigation (TAI) and its effect on the quality of life of children with spina bifida (SB) and anorectal malformations (ARM).

methodsSeventy-four pediatric patients (age 6-17 years) with SB and ARM with neurogenic bowel dysfunction were enrolled for a prospective and multicentric study. Patients were evaluated before the beginning of TAI (T0), after 3 months (T1) and after at least 2 years (range 24-32 months) (T2) using a questionnaire assessing bowel function, the Bristol scale, and two validated questionnaires on quality of life: the CHQ-PF50 questionnaire for the parents of patients aged 6-11 years and the SF36 questionnaires for patients aged between 12 and 18 years.

resultsSeventy-two patients completed TAI program in T1, and 67 continued into T2. Bowel outcomes (constipation and fecal incontinence) improved in both the SB and the ARM groups in the short and mid-long term. In both groups at T1 and T2, parents and children reported an improvement in quality of life and there was a significant increase of stool form types 4 and 5 as described by the Bristol scale. Common adverse effects during the study were similar at T1 and T2 without serious complications.

conclusionsWe observed a sustained improvement in bowel management and quality of life in SB and ARM children during the study, more significant in the short term than in mid-long term. To maintain success rates in the mid-long term and to reduce the dropout rate, we propose patient training and careful follow-ups.

Indexed as

AdolescentAnorectal MalformationsChildFemaleHumansMaleNeurogenic BowelQuality of LifeSpinal DysraphismTherapeutic IrrigationTreatment OutcomeAnorectal malformationConstipationFecal incontinenceQuality of lifeSpina bifidaTransanal irrigation

Identifiers

PMID29948136
OpenAlexW2808367022

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.