Evidence map›Paper›PMID 29948065›Full record

Trial reportEuropean radiology2018

Strain analysis is superior to wall thickening in discriminating between infarcted myocardium with and without microvascular obstruction.

Henk Everaars, Lourens F H J Robbers, Marco Götte, Pierre Croisille, Alexander Hirsch, Paul F A Teunissen, Peter M van de Ven, Niels van Royen, Felix Zijlstra, Jan J Piek and 2 more

Open access · hybridAbstract readClinical Trial
In one paragraph

Trial report in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

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  12. Hybrid PET/MR imaging in myocardial inflammation post-myocardial infarction.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Henk EveraarsDepartment of Cardiology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. h.everaars@vumc.nl.ORCID http://orcid.org/0000-0002-4521-0664
Lourens F H J RobbersDepartment of Cardiology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Marco GötteDepartment of Cardiology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Pierre CroisilleCreatis Medical Imaging Research Center, Lyon, France.
Alexander HirschDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.
Paul F A TeunissenDepartment of Cardiology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Peter M van de VenDepartment of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands.
Niels van RoyenDepartment of Cardiology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Felix ZijlstraDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.
Jan J PiekDepartment of Cardiology, Amsterdam Medical Center, Amsterdam, The Netherlands.
Albert C van RossumDepartment of Cardiology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Robin NijveldtDepartment of Cardiology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Amsterdam UMC Location Vrije Universiteit Amsterdam · NLNetherlands Heart Institute · NLCentre de Recherche en Acquisition et Traitement de l'Image pour la Santé · FRErasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of the present study was to evaluate the diagnostic performances of strain and wall thickening analysis in discriminating among three types of myocardium after acute myocardial infarction: non-infarcted myocardium, infarcted myocardium without microvascular obstruction (MVO) and infarcted myocardium with MVO.

methodsSeventy-one patients with a successfully treated ST-segment elevation myocardial infarction underwent cardiovascular magnetic resonance imaging at 2-6 days after reperfusion. The imaging protocol included conventional cine imaging, myocardial tissue tagging and late gadolinium enhancement. Regional circumferential and radial strain and associated strain rates were analyzed in a 16-segment model as were the absolute and relative wall thickening.

resultsHyperenhancement was detected in 418 (38%) of 1096 segments and was accompanied by MVO in 145 (35%) of hyperenhanced segments. Wall thickening, circumferential and radial strain were all significantly diminished in segments with hyperenhancement and decreased even further if MVO was also present (all p < 0.001). Peak circumferential strain (CS) surpassed all other strain and wall thickening parameters in its ability to discriminate between hyperenhanced and non-enhanced myocardium (all p < 0.05). Furthermore, CS was superior to both absolute and relative wall thickening in differentiating infarcted segments with MVO from infarcted segments without MVO (p = 0.02 and p = 0.001, respectively).

conclusionsStrain analysis is superior to wall thickening in differentiating between non-infarcted myocardium, infarcted myocardium without MVO and infarcted myocardium with MVO. Peak circumferential strain is the most accurate marker of regional function. KEY POINTS: • CMR can quantify regional myocardial function by analysis of wall thickening on cine images and strain analysis of tissue tagged images. • Strain analysis is superior to wall thickening in differentiating between different degrees of myocardial injury after acute myocardial infarction. • Peak circumferential strain is the most accurate marker of regional function.

Indexed as

FemaleHeart VentriclesHumansMagnetic Resonance Imaging, CineMaleMiddle AgedMyocardial ContractionMyocardial RevascularizationMyocardiumPrognosisST Elevation Myocardial InfarctionVentricular Function, LeftLeft ventricular functionMagnetic resonance ImagingMyocardial contractionST elevation myocardial infarction

Identifiers

PMID29948065
PMCPMC6223851
OpenAlexW2806326499

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.