ArticleSkeletal radiology2018
Effects of post-fracture non-weight-bearing immobilization on muscle atrophy, intramuscular and intermuscular adipose tissues in the thigh and calf.
Article in Skeletal radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Automatability and validity of methods for the quantification of intra-/Intermuscular adipose tissue in conventional MRI: a systematic review.BMC medical imaging · 2025Pooled it
- Rehabilitation for ankle fractures in adults.The Cochrane database of systematic reviews · 2024Pooled it
- Outcomes of early versus delayed weight-bearing with intramedullary nailing of tibial shaft fractures: a systematic review and meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Pooled it
- Is an Ambulatory Biofeedback Device More Effective than Instructing Partial Weight-Bearing Using a Bathroom Scale? Results of a Randomized Controlled Trial with Healthy Subjects.Sensors (Basel, Switzerland) · 2024Trial
- Prospective randomized controlled trial: early weight bearing after conservative treatment of Weber B ankle fractures (pancake trial).European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Trial
- Effects of 8 weeks of bed rest with or without resistance exercise intervention on the volume of the muscle tissue and the adipose tissues of the thigh.Physiological reports · 2020Trial
- [Osteosynthesis for tibial plateau fractures in geriatric patients].Unfallchirurgie (Heidelberg, Germany) · 2026Review
- Effects of bed rest and immobilization on intramuscular and intermuscular adipose tissue: A systematic review.Experimental physiology · 2026Review
- Epimuscular fat and its clinical relevance: a narrative review focused on paraspinal muscles.Quantitative imaging in medicine and surgery · 2026Review
- Acute changes in diffusion tensor imaging parameters of the quadriceps femoris muscle after stretching and their relationship with intramuscular adipose tissue.European journal of applied physiology · 2025Article
- Changes to muscle and fascia tissue after eighteen days of ankle immobilization post-ankle sprain injury: an MRI case study.BMC musculoskeletal disorders · 2025Article
- Early resistance rehabilitation improves functional regeneration following segmental bone defect injury.NPJ Regenerative medicine · 2024Article
- Feasibility of a new bicycle ergometer with adjustable pedaling configuration for personalized lower limb rehabilitation.Scientific reports · 2024Article
- Efficacy of neuromuscular electrical stimulation and interrupted serial casting in children with spastic diplegia.Journal of Taibah University Medical Sciences · 2024Article
- Walking with unilateral ankle-foot unloading: a comparative biomechanical analysis of three assistive devices.Journal of neuroengineering and rehabilitation · 2024Article
- Decreased rotator cuff muscle cross-sectional areas in subjects with adhesive capsulitis: a study comparing male and female subjects.Skeletal radiology · 2024Article
- Sex-Related Differences of Weight Bearing and Non-Weight Bearing Muscle Properties.Muscles (Basel, Switzerland) · 2023Article
- A non-invasive mouse model that recapitulates disuse-induced muscle atrophy in immobilized patients.Scientific reports · 2023Article
- Early Resistance Rehabilitation Improves Functional Regeneration Following Segmental Bone Defect Injury.Research square · 2023Article
- Passive muscle stiffness is correlated with the intramuscular adipose tissue in young individuals.European journal of applied physiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDisuse and/or a non-weight-bearing condition changes muscle composition, with decreased skeletal muscle tissue and increased fat within (intramuscular adipose tissue, IntraMAT) and between (intermuscular adipose tissue, InterMAT) given muscles. Excessive adipose tissue contributes to dysfunctional and metabolically impaired muscle. How these adipose tissues change during orthopedic treatment (e.g., cast immobilization, daily use of crutches) is not well documented. This study aimed to quantify changes in IntraMAT, InterMAT, and thigh and calf muscle tissue during orthopedic treatment. MATERIALS AND
methodsWe studied 8 patients with fifth metatarsal bone or fibular fractures. The ankle joint involved underwent plaster casting for approximately 4 weeks, with crutches used during that time. Axial T1-weighted MRI at the mid-thigh and a 30% proximal site at the calf were obtained to measure IntraMAT and InterMAT cross-sectional areas (CSAs) and skeletal muscle tissue CSA before treatment and 4 weeks afterward.
resultsThigh and calf muscle tissue CSAs were significantly decreased from before to after treatment: thigh, 85.8 ± 7.6 to 77.1 ± 7.3 cm
conclusionsThe 4 weeks of treatment primarily induced skeletal muscle atrophy with less of an effect on IntraMAT or InterMAT. There is a risk of increasing IntraMAT relatively by decreasing skeletal muscle tissue size during orthopedic treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.