Evidence map›Paper›PMID 29947969›Full record

ReviewCurrent genetics2019

Chromatin mobility upon DNA damage: state of the art and remaining questions.

Christophe Zimmer, Emmanuelle Fabre

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Chromothripsis.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
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  4. DNA damage reduces heterogeneity and coherence of chromatin motions.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
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  7. Article
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  20. Complex Chromatin Motions for DNA Repair.Frontiers in genetics · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christophe ZimmerUnité Imagerie et Modélisation, Institut Pasteur, 25 rue du Docteur Roux, 75015, Paris, France. christophe.zimmer@pasteur.fr.
Emmanuelle FabreEquipe Biologie et Dynamique des Chromosomes, Institut Universitaire d'Hématologie, Hôpital St. Louis, Paris, France. emmanuelle-g.fabre@inserm.fr.ORCID http://orcid.org/0000-0002-0009-4604

Funding

Agence Nationale de la Recherche (FR) ANR-13-BSV8-0013-01Cancéropôle Île-de-France ORFOCRISE PME-2015FRM DEQ20150331762FRM ING20160435205)IDEX DXCAIUHSLI-EF14INCA 2015-135LaBEX WAI ANR-11-LABX-0071LABEX WAI ANR-11-IDEX-0005-02
6 · The paper itself

Abstract

Chromosome organization and chromatin mobility are central to DNA metabolism. In particular, it has been recently shown by several labs that double strand breaks (DSBs) in yeast induce a change in chromatin mobility at the site of the damage. Intriguingly, DSB also induces a global mobility of the genome, at others, potentially undamaged positions. How mobility is regulated and what are the functional outcomes of these global changes in chromatin dynamics are, however, not yet fully understood. We present the current state of knowledge in light of the recent literature and discuss some perspectives opened by these discoveries towards genome stability.

Indexed as

DNA Breaks, Double-StrandedDNA RepairAnimalsChromatinDNAGenomic InstabilityHistonesHumansPhosphorylationSaccharomyces cerevisiaeChromatinDNAHistonesChromatinDouble strand breaksMobilityPolymer physicsYeast

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.