ArticlePsychopharmacology2018
Compulsive sucrose- and cocaine-seeking behaviors in male and female Wistar rats.
Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The influence of sex and reproductive cycle on cocaine-induced behavioral and neurobiological alterations: a review.Experimental brain research · 2022Pooled it
- The recreational-to-habitual shift in psychostimulant use is an economic demand parameter that is unrelated to drug consumption levels (under normal and punishment conditions).bioRxiv : the preprint server for biology · 2026Article
- Article
- Sex-dependent effects of food-restriction on cocaine self-administration and cocaine-seeking in rats.Frontiers in behavioral neuroscience · 2025Article
- Random interval schedule of reinforcement influences punishment resistance for cocaine in rats.Neurobiology of learning and memory · 2024Article
- Punishment resistance for cocaine is associated with inflexible habits in rats.Addiction neuroscience · 2024Article
- Delay of punishment highlights differential vulnerability to developing addiction-like behavior toward sweet food.Translational psychiatry · 2024Article
- Microarray Analysis of Visceral Adipose Tissue in Obese Women Reveals Common Crossroads Among Inflammation, Metabolism, Addictive Behaviors, and Cancer: AKT3 and MAPK1 Cross Point in Obesity.Journal of obesity · 2024Article
- Circulating ovarian hormones interact with protein interacting with C kinase (PICK1) within the medial prefrontal cortex to influence cocaine seeking in female mice.Hormones and behavior · 2023Article
- Pathways to the persistence of drug use despite its adverse consequences.Molecular psychiatry · 2023Review
- Increased responsiveness to punishment of cocaine self-administration after experience with high punishment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Animal Models of the Behavioral Symptoms of Substance Use Disorders.Cold Spring Harbor perspectives in medicine · 2021Review
- The effects of strain and estrous cycle on heroin- and sugar-maintained responding in female rats.Behavioural brain research · 2021Article
- Role of the GABAPsychopharmacology · 2020Article
- Sex differences in the glutamate system: Implications for addiction.Neuroscience and biobehavioral reviews · 2020Review
- Interfacing behavioral and neural circuit models for habit formation.Journal of neuroscience research · 2020Review
- Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Contribution of the prefrontal cortex and basolateral amygdala to behavioral decision-making under reward/punishment conflict.Psychopharmacology · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
rationaleCompulsive cocaine use is a key feature of cocaine addiction and understanding the factors that promote the development of such a behavior will provide important insights into the mechanism of cocaine addiction and is essential for the clinical management of the disorder.
objectivesThis study aimed to determine how the preexisting compulsive reward-seeking behavior is related to the development of compulsive cocaine-seeking behavior in male and female rats and the potential impact of the reward value and estrous cycle on such behaviors.
methodsAdult male and female Wistar rats were first trained to self-administer sucrose pellets under a chained schedule, and then, the intensity-response effects of footshock punishment on sucrose SA reinforced by different values of sucrose were measured. Subsequently, the same rats went on to self-administer intravenous cocaine and the punishment intensity-response effects on cocaine SA reinforced by different doses of cocaine were similarly determined. For the female rats, the measurements were made during different phases of the estrous cycle.
resultsThe rats showed a wide range of levels of the compulsive behaviors despite the similar training history. Surprisingly, the compulsive sucrose-seeking behavior did not predict the compulsive cocaine-seeking behavior in either sex. Increasing cocaine dose significantly increased the compulsive cocaine-seeking behavior in the female but not male rats. Estrous cycle did not have impact on the compulsive behaviors.
conclusionPreexisting differences in compulsive sucrose-seeking behavior do not predict compulsive cocaine-seeking behavior. Compulsive cocaine-seeking behavior is influenced by cocaine dose but not estrous cycle in the female rats.
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