ArticleIntensive care medicine2018
Impact of the driving pressure on mortality in obese and non-obese ARDS patients: a retrospective study of 362 cases.
Article in Intensive care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Effect of driving pressure-limiting strategies on outcomes of patients with ARDS: a meta-analysis of randomized controlled trials.Critical care (London, England) · 2026Pooled it
- Driving pressure-limited ventilation strategies versus conventional lung protective ventilation strategies for patients with ARDS/ARF: a systematic review and meta-analysis of randomized controlled trials.Critical care (London, England) · 2025Pooled it
- Noninvasive ventilation on reintubation in patients with obesity and hypoxemic respiratory failure following abdominal surgery: a post hoc analysis of a randomized clinical trial.Intensive care medicine · 2024Trial
- Advanced respiratory mechanics assessment in mechanically ventilated obese and non-obese patients with or without acute respiratory distress syndrome.Critical care (London, England) · 2023Trial
- ECMO for patients with obesity: evidence and practice.Intensive care medicine · 2026Review
- Obesity: biomechanical implications for mechanical ventilation.Critical care (London, England) · 2026Review
- Mechanical ventilation for ICU patient with obesity: current best practices and future directions.Intensive care medicine · 2026Review
- Morphological subphenotypes of acute pancreatitis-related acute respiratory distress syndrome.Critical care (London, England) · 2026Article
- Predictors of VV-ECMO weaning safety: longitudinal ventilatory ratio assessment during sweep gas off trials, a retrospective cohort study.BMC anesthesiology · 2025Article
- Body mass index, ventilator parameters, and mortality in acute respiratory distress syndrome: re-examining the obesity paradox.Journal of thoracic disease · 2025Article
- High-fat diet obesity exacerbates acute lung injury-induced dysregulation of fatty acid oxidation in alveolar epithelial type 2 cells.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Reply to HuaAmerican journal of respiratory and critical care medicine · 2025Article
- Managing Refractory Hypoxemia in Acute Respiratory Distress Syndrome Obese Patients with Veno-Venous Extra-Corporeal Membrane Oxygenation: A Narrative Review.Journal of clinical medicine · 2025Review
- Optimizing Mechanical Ventilation Strategies in ARDS: The Role of Driving Pressure and Low Tidal Volume Ventilation.Critical care research and practice · 2025Review
- Acute Respiratory Distress Syndrome: No Disease for Old Men.American journal of respiratory and critical care medicine · 2024Article
- Comparing the impact of targeting limited driving pressure to low tidal volume ventilation on mortality in mechanically ventilated adults with COVID-19 ARDS: an exploratory target trial emulation.BMJ open respiratory research · 2024Article
- Driving pressure in mechanical ventilation: A review.World journal of critical care medicine · 2024Review
- Physical and respiratory therapy in the critically ill patient with obesity: a narrative review.Frontiers in medicine · 2024Review
- Physiologic Markers of Disease Severity in ARDS.Respiratory care · 2023Review
- Outcomes and time trends of acute respiratory distress syndrome patients with and without liver cirrhosis: an observational cohort.Annals of intensive care · 2023Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe relation between driving pressure (plateau pressure-positive end-expiratory pressure) and mortality has never been studied in obese ARDS patients. The main objective of this study was to evaluate the relationship between 90-day mortality and driving pressure in an ARDS population ventilated in the intensive care unit (ICU) according to obesity status.
methodsWe conducted a retrospective single-center study of prospectively collected data of all ARDS patients admitted consecutively to a mixed medical-surgical adult ICU from January 2009 to May 2017. Plateau pressure, compliance of the respiratory system (Crs) and driving pressure of the respiratory system within 24 h of ARDS diagnosis were compared between survivors and non-survivors at day 90 and between obese (body mass index ≥ 30 kg/m
resultsThree hundred sixty-two ARDS patients were included, 262 (72%) non-obese and 100 (28%) obese patients. Mortality rate at day 90 was respectively 47% (95% CI, 40-53) in the non-obese and 46% (95% CI, 36-56) in the obese patients. Driving pressure at day 1 in the non-obese patients was significantly lower in survivors at day 90 (11.9 ± 4.2 cmH
conclusionsContrary to non-obese ARDS patients, driving pressure was not associated with mortality in obese ARDS patients.
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