Trial reportClinical neuroradiology2019
Susceptibility Vessel Sign and Cardioembolic Etiology in the THRACE Trial.
Trial report in Clinical neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome: a systematic review.Journal of neurointerventional surgery · 2017Pooled it
- Validation of overestimation ratio and TL-SVS as imaging biomarker of cardioembolic stroke and time from onset to MRI.European radiology · 2019Trial
- Two-Layered Susceptibility Vessel Sign and High Overestimation Ratio on MRI Are Predictive of Cardioembolic Stroke.AJNR. American journal of neuroradiology · 2019Trial
- Absence of the Susceptibility Vessel Sign with Cancer-Associated Hypercoagulability-Related Stroke.AJNR. American journal of neuroradiology · 2024Article
- Susceptibility vessel sign in patients with subacute ischemic stroke.Quantitative imaging in medicine and surgery · 2024Article
- Imaging diagnosis of intracranial atherosclerosis stenosis-related large vessel occlusion before and during endovascular therapy.Frontiers in neurology · 2023Review
- Factors That Influence Susceptibility Vessel Sign in Patients With Acute Stroke Referred for Mechanical Thrombectomy.Frontiers in neurology · 2022Article
- Predictive value of thrombus susceptibility for cardioembolic stroke by quantitative susceptibility mapping.Quantitative imaging in medicine and surgery · 2022Article
- [Susceptibility vessel sign in subacute stroke patients with large vessel occlusion].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2021Article
- In Vitro Study of Blood Clot Identification and Composition Assessment by Different Magnetic Resonance Sequences.Cureus · 2021Article
- Impact of Clot Shape on Successful M1 Endovascular Reperfusion.Frontiers in neurology · 2021Article
- FLAIR vascular hyperintensity-DWI mismatch most likely to benefit from recanalization and good outcome after stroke.Medicine · 2020Observational
- Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome.Journal of neurosurgical sciences · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe susceptibility vessel sign (SVS) has been described on gradient echo (GRE) magnetic resonance imaging (MRI) in acute ischemic stroke patients by large vessel occlusion. The presence of SVS (SVS+) was associated with treatment outcome and stroke etiology with conflicting results. Based on multicenter data from the THRombectomie des Artères CErebrales (THRACE) study, we aimed to determine if the association between SVS and cardioembolic etiology (CE) was independent of GRE sequence parameters. MATERIAL AND
methodsPatients with a pretreatment brain GRE sequence were identified. Logistic regression tested the association between SVS+, CE, time from onset to imaging and GRE sequence parameters (e.g. echo time, voxel size, field strength). We calculated the sensitivity, specificity, positive and negative predictive values (PPV and NPV) for the SVS to predict a stroke from a CE.
resultsAn SVS+ was observed in 237 out of 287 (83%) patients. In the univariate analysis, there was a significant association between SVS+ and a CE with an odds ratio (OR) and 95% confidence interval (95% CI) of 2.10 (1.02-4.29), respectively (p = 0.04) but not with GRE sequence parameters. In multivariate analysis, there was an independent relationship between SVS+ and CE (OR [95% CI]: 2.14 [1.02-4.45], p = 0.04). Sensitivity and specificity of SVS+ to predict CE were 0.89 and 0.21, respectively. The PPV and NPV of SVS+ were 0.44 and 0.78, respectively.
conclusionThe presence of SVS is associated to CE, independent of GRE sequence parameters. While the specificity and the PPV of the sign were low, CE seems less likely in the absence of an SVS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.