ArticleNanoscale2018
Perfluorocarbon-loaded polydopamine nanoparticles as ultrasound contrast agents.
Article in Nanoscale, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 38 citations in OpenAlex.
- A Comprehensive Review: Versatile Imaging Probe Based on Chemical Materials for Biomedical Applications.Applied biochemistry and biotechnology · 2025Review
- Polydopamine Nanobowl-Armoured Perfluorocarbon Emulsions: Tracking Thermal- and Photothermal-Induced Phase Change through Neutron Scattering.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Laser-activated nanoparticles for ultrasound/photoacoustic imaging-guided prostate cancer treatment.Frontiers in bioengineering and biotechnology · 2023Article
- Multifunctional liposome for photoacoustic/ultrasound imaging-guided chemo/photothermal retinoblastoma therapy.Drug delivery · 2022Article
- Extrusion: A New Method for Rapid Formulation of High-Yield, Monodisperse Nanobubbles.Small (Weinheim an der Bergstrasse, Germany) · 2022Article
- Phenolic-enabled nanotechnology: versatile particle engineering for biomedicine.Chemical Society reviews · 2021Review
- Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications.Beilstein journal of nanotechnology · 2021Review
- Article
- Contrast enhanced ultrasound imaging by nature-inspired ultrastable echogenic nanobubbles.Nanoscale · 2019Article
- Tuning the ultrasonic and photoacoustic response of polydopamine-stabilized perfluorocarbon contrast agents.Journal of materials chemistry. B · 2019Article
- Sink or float? Characterization of shell-stabilized bulk nanobubbles using a resonant mass measurement technique.Nanoscale · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
A versatile platform for the development of new ultrasound contrast agents is demonstrated through a one-pot synthesis and fluorination of submicron polydopamine (PDA-F) nanoparticles. The fluorophilicity of these particles allows loading with perfluoropentane (PFP) droplets that display strong and persistent ultrasound contrast in aqueous suspension and ex vivo tissue samples. Contrast under continuous imaging by color Doppler persists for 1 h in 135 nm PDA-F samples, even at maximum clinical imaging power (MI = 1.9). Additionally, use of a Cadence Contrast Pulse Sequence (CPS) results in a non-linear response suitable for imaging at 0.5 mg mL-1. Despite the PFP volatility and the lack of a hollow core, PDA-F particles display minimal signal loss after storage for over a week. The ability to tune size, metal-chelation, and add covalently-bound organic functionality offers myriad possibilities for extending this work to multimodal imaging, targeted delivery, and therapeutic functionality.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.