ArticleJournal of psychiatry & neuroscience : JPN2018
The maternal brain in women with a history of early-life maltreatment: an imagination-based fMRI study of conflictual versus pleasant interactions with children.
Article in Journal of psychiatry & neuroscience : JPN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Neural Correlates of Maternal Posttraumatic Stress in the First Postpartum Year: Blunted Salience and Prefrontal Responses to Infant Distress.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Article
- Persistent dopamine-dependent remodeling of the neural transcriptome in response to pregnancy and postpartum.bioRxiv : the preprint server for biology · 2025Article
- Parents of Child Psychiatric Patients Report More Adverse Childhood Experiences Compared with Community Samples.Children (Basel, Switzerland) · 2024Article
- Stress and reward in the maternal brain of mothers with borderline personality disorder: a script-based fMRI study.European archives of psychiatry and clinical neuroscience · 2024Article
- Maternal History of Childhood Maltreatment and Brain Responses to Infant Cues Across the Postpartum Period.Child maltreatment · 2024Article
- Do I care for you or for me? Processing of protected and non-protected moral values in subjects with extreme scores on the Dark Triad.European archives of psychiatry and clinical neuroscience · 2023Article
- Emotional Availability in Mother-Child and Father-Child Interactions as Predictors of Child's Attachment Representations in Adoptive Families.International journal of environmental research and public health · 2022Article
- Neurobiological Implications of Parent-Child Emotional Availability: A Review.Brain sciences · 2021Review
- How stress can influence brain adaptations to motherhood.Frontiers in neuroendocrinology · 2021Review
- Chronic trauma impairs the neural basis of empathy in mothers: Relations to parenting and children's empathic abilities.Developmental cognitive neuroscience · 2019Article
- [Impact of early life maltreatment of women on the mother-child relationship : Data from mother-child dyads from Heidelberg and Berlin].Der Nervenarzt · 2019Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly-life maltreatment has severe consequences for the affected individual, and it has an impact on the next generation. To improve understanding of the intergenerational effects of abuse, we investigated the consequences of early-life maltreatment on maternal sensitivity and associated brain mechanisms during mother-child interactions.
methodsIn total, 47 mothers (22 with a history of physical and/or sexual childhood abuse and 25 without, all without current mental disorders) took part in a standardized real-life interaction with their 7- to 11-year-old child (not abused) and a subsequent functional imaging script-driven imagery task.
resultsMothers with early-life maltreatment were less sensitive in real-life mother-child interactions, but while imagining conflictual interactions with their child, they showed increased activation in regions of the salience and emotion-processing network, such as the amygdala, insula and hippocampus. This activation pattern was in contrast to that of mothers without early-life maltreatment, who showed higher activations in those regions in response to pleasant mother-child interactions. Mothers with early-life maltreatment also showed reduced functional connectivity between regions of the salience and the mentalizing networks. LIMITATIONS: Region-of-interest analyses, which were performed in addition to whole-brain analyses, were exploratory in nature, because they were not further controlled for multiple comparisons.
conclusionResults suggest that for mothers with early-life maltreatment, conflictual interactions with their child may be more salient and behaviourally relevant than pleasant interactions, and that their salience network is poorly modulated by the brain regions involved in mentalizing processes. This activation pattern offers new insights into the mechanisms behind the intergenerational effects of maltreatment and into options for reducing these effects.
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