ArticleJournal of psychiatry & neuroscience : JPN2018
Abnormal dynamic functional connectivity of amygdalar subregions in untreated patients with first-episode major depressive disorder.
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Article in Journal of psychiatry & neuroscience : JPN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed.
- Effects of light therapy on amygdala connectivity and serotoninergic system in young adults with subthreshold depression.Dialogues in clinical neuroscience · 2025Trial
- Abnormal Dynamic Functional Connectivity Within the Fronto-Limbic Network Mediates the Association Between Depressive Symptoms and Non-Suicidal Self-Injury in Adolescents.CNS neuroscience & therapeutics · 2026Article
- The role of the subcortical structures in subthreshold depression: evidence from static and dynamic functional connectivity.Brain structure & function · 2026Article
- Distinct Trajectories of Amygdala Connectivity Patterns Characterize Remission vs. Non-Remission in Patients With Major Depressive Disorder.Depression and anxiety · 2026Article
- Subregional amygdala functional connectivity abnormalities and anhedonia impairments in first-episode schizophrenia.BMC psychiatry · 2025Article
- Altered dynamic functional connectivity in antagonistic state in first-episode, drug-naïve patients with major depressive disorder.BMC psychiatry · 2024Article
- Trait-anxiety and glial-related neuroinflammation of the amygdala and its associated regions in Alzheimer's disease: A significant correlation.Brain, behavior, & immunity - health · 2024Article
- The association between gray matter volume in the hippocampal subfield and antidepressant efficacy mediated by abnormal dynamic functional connectivity.Scientific reports · 2024Article
- Alterations of amygdala volume and functional connectivity in migraine patients comorbid with and without depression.Brain and behavior · 2024Article
- Altered brain texture features in end-stage renal disease patients: a voxel-based 3D brain texture analysis study.Frontiers in neuroscience · 2024Article
- Transcriptional signatures of the cortical morphometric similarity network gradient in first-episode, treatment-naive major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- AI-based dimensional neuroimaging system for characterizing heterogeneity in brain structure and function in major depressive disorder: COORDINATE-MDD consortium design and rationale.BMC psychiatry · 2023Article
- Performances of whole-brain dynamic and static functional connectivity fingerprinting in machine learning-based classification of major depressive disorder.Frontiers in psychiatry · 2022Article
- Shared and distinct patterns of dynamical degree centrality in bipolar disorder across different mood states.Frontiers in psychiatry · 2022Article
- Temporal variability of regional intrinsic neural activity in drug-naïve patients with obsessive-compulsive disorder.Human brain mapping · 2021Article
- Tools of the trade: estimating time-varying connectivity patterns from fMRI data.Social cognitive and affective neuroscience · 2021Review
- Differential Dynamical Pattern of Regional Homogeneity in Bipolar and Unipolar Depression: A Preliminary Resting-State fMRI Study.Frontiers in psychiatry · 2021Article
- Effective Connectivity of Right Amygdala Subregions Predicts Symptom Improvement Following 12-Week Pharmacological Therapy in Major Depressive Disorder.Frontiers in neuroscience · 2021Article
- Abnormal Functional Connectivity of Posterior Cingulate Cortex Correlates With Phonemic Verbal Fluency Deficits in Major Depressive Disorder.Frontiers in neurology · 2021Article
- Improving Emotion Regulation Through Real-Time Neurofeedback Training on the Right Dorsolateral Prefrontal Cortex: Evidence From Behavioral and Brain Network Analyses.Frontiers in human neuroscience · 2021Article
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Authors and funding
12 authors.
Lihua QiuFrom the Huaxi MR Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu, Chen, Lui, Huang, Gong); the Department of Radiology, The Second People's Hospital of Yibin, Yibin, China (Qiu); the National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China (Xia, Yuan, He); the Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China (Xia, He); the IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Xia, He); the Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Kuang); the Department of Oncology, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Bi); the National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu, Sichuan, China (Ai, Gu).
Mingrui XiaFrom the Huaxi MR Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu, Chen, Lui, Huang, Gong); the Department of Radiology, The Second People's Hospital of Yibin, Yibin, China (Qiu); the National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China (Xia, Yuan, He); the Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China (Xia, He); the IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Xia, He); the Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Kuang); the Department of Oncology, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Bi); the National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu, Sichuan, China (Ai, Gu).
Bochao ChengFrom the Huaxi MR Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu, Chen, Lui, Huang, Gong); the Department of Radiology, The Second People's Hospital of Yibin, Yibin, China (Qiu); the National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China (Xia, Yuan, He); the Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China (Xia, He); the IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Xia, He); the Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Kuang); the Department of Oncology, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Bi); the National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu, Sichuan, China (Ai, Gu).
Lin YuanFrom the Huaxi MR Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu, Chen, Lui, Huang, Gong); the Department of Radiology, The Second People's Hospital of Yibin, Yibin, China (Qiu); the National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China (Xia, Yuan, He); the Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China (Xia, He); the IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Xia, He); the Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Kuang); the Department of Oncology, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Bi); the National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu, Sichuan, China (Ai, Gu).
Weihong KuangFrom the Huaxi MR Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu, Chen, Lui, Huang, Gong); the Department of Radiology, The Second People's Hospital of Yibin, Yibin, China (Qiu); the National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China (Xia, Yuan, He); the Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China (Xia, He); the IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Xia, He); the Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Kuang); the Department of Oncology, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Bi); the National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu, Sichuan, China (Ai, Gu).
Feng BiFrom the Huaxi MR Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu, Chen, Lui, Huang, Gong); the Department of Radiology, The Second People's Hospital of Yibin, Yibin, China (Qiu); the National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China (Xia, Yuan, He); the Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China (Xia, He); the IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Xia, He); the Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Kuang); the Department of Oncology, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Bi); the National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu, Sichuan, China (Ai, Gu).
Hua AiFrom the Huaxi MR Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu, Chen, Lui, Huang, Gong); the Department of Radiology, The Second People's Hospital of Yibin, Yibin, China (Qiu); the National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China (Xia, Yuan, He); the Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China (Xia, He); the IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Xia, He); the Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Kuang); the Department of Oncology, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Bi); the National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu, Sichuan, China (Ai, Gu).
Zhongwei GuFrom the Huaxi MR Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu, Chen, Lui, Huang, Gong); the Department of Radiology, The Second People's Hospital of Yibin, Yibin, China (Qiu); the National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China (Xia, Yuan, He); the Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China (Xia, He); the IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Xia, He); the Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Kuang); the Department of Oncology, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Bi); the National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu, Sichuan, China (Ai, Gu).
Su LuiFrom the Huaxi MR Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu, Chen, Lui, Huang, Gong); the Department of Radiology, The Second People's Hospital of Yibin, Yibin, China (Qiu); the National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China (Xia, Yuan, He); the Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China (Xia, He); the IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Xia, He); the Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Kuang); the Department of Oncology, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Bi); the National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu, Sichuan, China (Ai, Gu).
Xiaoqi HuangFrom the Huaxi MR Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu, Chen, Lui, Huang, Gong); the Department of Radiology, The Second People's Hospital of Yibin, Yibin, China (Qiu); the National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China (Xia, Yuan, He); the Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China (Xia, He); the IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Xia, He); the Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Kuang); the Department of Oncology, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Bi); the National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu, Sichuan, China (Ai, Gu).
Yong HeFrom the Huaxi MR Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu, Chen, Lui, Huang, Gong); the Department of Radiology, The Second People's Hospital of Yibin, Yibin, China (Qiu); the National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China (Xia, Yuan, He); the Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China (Xia, He); the IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Xia, He); the Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Kuang); the Department of Oncology, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Bi); the National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu, Sichuan, China (Ai, Gu).
Qiyong GongFrom the Huaxi MR Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu, Chen, Lui, Huang, Gong); the Department of Radiology, The Second People's Hospital of Yibin, Yibin, China (Qiu); the National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China (Xia, Yuan, He); the Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China (Xia, He); the IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Xia, He); the Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Kuang); the Department of Oncology, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Bi); the National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu, Sichuan, China (Ai, Gu).
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccumulating evidence supports the concept of the amygdala as a complex of structurally and functionally heterogeneous nuclei rather than as a single homogeneous structure. However, changes in resting-state functional connectivity in amygdalar subregions have not been investigated in major depressive disorder (MDD). Here, we explored whether amygdalar subregions - including the laterobasal, centromedial (CM) and superficial (SF) areas - exhibited distinct disruption patterns for different dynamic functional connectivity (dFC) properties, and whether these different properties were correlated with clinical information in patients with MDD.
methodsThirty untreated patients with first-episode MDD and 62 matched controls were included. We assessed between-group differences in the mean strength of dFC in each amygdalar subregion in the whole brain using general linear model analysis.
resultsThe patients with MDD showed decreased strength in positive dFC between the left CM/SF and brainstem and between the left SF and left thalamus; they showed decreased strength in negative dFC between the left CM and right superior frontal gyrus ( LIMITATIONS: The definitions of amygdalar subregions were based on a cytoarchitectonic delineation, and the temporal resolution of the fMRI was slow (repetition time = 2 s).
conclusionThese findings confirm the distinct dynamic functional pathway of amygdalar subregions in MDD and suggest that the limbic-cortical-striato-pallido-thalamic circuitry plays a crucial role in the early stages of MDD.
Indexed as
AdolescentAdultAgedAged, 80 and overAge of OnsetAmygdalaBrain StemCase-Control StudiesFemaleHumansMagnetic Resonance ImagingMajor Depressive DisorderMaleMiddle AgedNeural PathwaysPrefrontal Cortex
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29947609PMC
PMC6019355What OpenQuestion holds
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