ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2018
Organs from deceased donors with false-positive HIV screening tests: An unexpected benefit of the HOPE act.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Hope for kidney transplantation in candidates with human immunodeficiency virus.World journal of transplantation · 2026Review
- Kaposi Sarcoma-Associated Herpesvirus Risk and Disease in Kidney Donors and Transplant Recipients With HIV in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Human antibody repertoire among kidney donors with and without HIV.JCI insight · 2026Article
- Influence of HIV Status on Organ Procurement and Allocation: A Discrete Choice Experiment of Australian Transplant Providers.Open forum infectious diseases · 2026Article
- Potential pool of cardiothoracic organs from donors with HIV.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026Article
- Increased rate of deceased donor liver transplantation for candidates willing to receive organs from donors with human immunodeficiency virus.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Article
- Solid organ transplantation in people with HIV: Outcomes, obstacles and opportunities.HIV medicine · 2025Review
- Inflammation among kidney transplant donors with and without HIV: Multicenter HOPE in Action Consortium.Clinical immunology (Orlando, Fla.) · 2025Article
- Evaluating Challenges in Access To Transplantation for Persons with HIV.Current HIV/AIDS reports · 2025Review
- Safety of Kidney Transplantation from Donors with HIV.The New England journal of medicine · 2024Observational
- Liver Transplantation in People Living with HIV: Still an Experimental Procedure or Standard of Care?Life (Basel, Switzerland) · 2023Review
- Efficacy of hope: Analysis of organ quality and availability among deceased HIV-positive donors.Transplant infectious disease : an official journal of the Transplantation Society · 2022Article
- HIV at 40: kidney disease in HIV treatment, prevention, and cure.Kidney international · 2022Review
- National Landscape of Human Immunodeficiency Virus-Positive Deceased Organ Donors in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- HOPE in action: A prospective multicenter pilot study of liver transplantation from donors with HIV to recipients with HIV.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- An Update on Usage of High-Risk Donors in Liver Transplantation.Journal of clinical medicine · 2021Review
- "Raising HOPE": Improved Outcomes for HIV/HCV-coinfected Liver Transplant Recipients in the Direct-acting Antiviral Era.Transplantation direct · 2021Article
- A prospective multicenter pilot study of HIV-positive deceased donor to HIV-positive recipient kidney transplantation: HOPE in action.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
- Update on liver transplantation-newer aspectsTurkish journal of medical sciences · 2020Review
- Organ transplantation in persons with HIV.AIDS (London, England) · 2020Review
Corrections and comments
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Authors and funding
22 authors at 8 institutions in 1 country.
Funding
Abstract
Organs from deceased donors with suspected false-positive HIV screening tests were generally discarded due to the chance that the test was truly positive. However, the HIV Organ Policy Equity (HOPE) Act now facilitates use of such organs for transplantation to HIV-infected (HIV+) individuals. In the HOPE in Action trial, donors without a known HIV infection who unexpectedly tested positive for anti-HIV antibody (Ab) or HIV nucleic acid test (NAT) were classified as suspected false-positive donors. Between March 2016 and March 2018, 10 suspected false-positive donors had organs recovered for transplant for 21 HIV + recipients (14 single-kidney, 1 double-kidney, 5 liver, 1 simultaneous liver-kidney). Median donor age was 24 years; cause of death was trauma (n = 5), stroke (n = 4), and anoxia (n = 1); three donors were labeled Public Health Service increased infectious risk. Median kidney donor profile index was 30.5 (IQR 22-58). Eight donors were HIV Ab+/NAT-; two were HIV Ab-/NAT+. All 10 suspected false-positive donors were confirmed to be HIV-noninfected. Given the false-positive rates of approved assays used to screen > 20 000 deceased donors annually, we estimate 50-100 HIV false-positive donors per year. Organ transplantation from suspected HIV false-positive donors is an unexpected benefit of the HOPE Act that provides another novel organ source.
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