Evidence map›Paper›PMID 29947266›Full record

ReviewThe British journal of radiology2018

A review on radiomics and the future of theranostics for patient selection in precision medicine.

Simon A Keek, Ralph Th Leijenaar, Arthur Jochems, Henry C Woodruff

Abstract readReview
In one paragraph

Review in The British journal of radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
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  8. Review
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  13. MulticentricFrontiers in nuclear medicine · 2023
    Article
  14. Review
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  16. Review
  17. Review
  18. A review on advances inInsights into imaging · 2022
    Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Simon A Keek1 The D-Lab: Decision Support for Precision Medicine GROW - School for Oncology and Developmental Biology & MCCC , Maastricht University Medical Centre+ , Maastricht , The Netherlands.
Ralph Th Leijenaar1 The D-Lab: Decision Support for Precision Medicine GROW - School for Oncology and Developmental Biology & MCCC , Maastricht University Medical Centre+ , Maastricht , The Netherlands.
Arthur Jochems1 The D-Lab: Decision Support for Precision Medicine GROW - School for Oncology and Developmental Biology & MCCC , Maastricht University Medical Centre+ , Maastricht , The Netherlands.
Henry C Woodruff1 The D-Lab: Decision Support for Precision Medicine GROW - School for Oncology and Developmental Biology & MCCC , Maastricht University Medical Centre+ , Maastricht , The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The growing complexity and volume of clinical data and the associated decision-making processes in oncology promote the advent of precision medicine. Precision (or personalised) medicine describes preventive and/or treatment procedures that take individual patient variability into account when proscribing treatment, and has been hindered in the past by the strict requirements of accurate, robust, repeatable and preferably non-invasive biomarkers to stratify both the patient and the disease. In oncology, tumour subtypes are traditionally measured through repeated invasive biopsies, which are taxing for the patient and are cost and labour intensive. Quantitative analysis of routine clinical imaging provides an opportunity to capture tumour heterogeneity non-invasively, cost-effectively and on large scale. In current clinical practice radiological images are qualitatively analysed by expert radiologists whose interpretation is known to suffer from inter- and intra-operator variability. Radiomics, the high-throughput mining of image features from medical images, provides a quantitative and robust method to assess tumour heterogeneity, and radiomics-based signatures provide a powerful tool for precision medicine in cancer treatment. This study aims to provide an overview of the current state of radiomics as a precision medicine decision support tool. We first provide an overview of the requirements and challenges radiomics currently faces in being incorporated as a tool for precision medicine, followed by an outline of radiomics' current applications in the treatment of various types of cancer. We finish with a discussion of possible future advances that can further develop radiomics as a precision medicine tool.

Indexed as

Patient SelectionForecastingHumansNeoplasmsPrecision MedicineRadiologyTheranostic Nanomedicine

Identifiers

PMID29947266
PMCPMC6475933

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.