ArticleHuman brain mapping2018
Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity.
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Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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41citing papers in PubMed, 2 pooled it
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41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Genetic meta-analysis of obsessive-compulsive disorder and self-report compulsive symptoms.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020Pooled it
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.Translational psychiatry · 2020Pooled it
- A randomized, double-blind, placebo-controlled phase II trial to explore the effects of a GABAJournal of neurodevelopmental disorders · 2022Trial
- Lifespan Trajectories of Resting State EEG power.bioRxiv : the preprint server for biology · 2026Article
- Electrophysiological resting-state signatures link polygenic scores to general intelligence.Scientific reports · 2025Observational
- Common Genomic and Proteomic Alterations Related to Disturbed Neural Oscillatory Activity in Schizophrenia.International journal of molecular sciences · 2025Review
- Digital psychiatry: concepts, framework, and implications.Frontiers in psychiatry · 2025Review
- Mitochondrial Dysfunction and Immune Cell Infiltration in Diabetic Kidney Disease: A Mendelian Randomization and Multiomics Study.Mediators of inflammation · 2025Article
- Preclinical pharmacology of alogabat: a novel GABAFrontiers in pharmacology · 2025Article
- Large-Scale Neuroimaging of Mental Illness.Current topics in behavioral neurosciences · 2024Review
- The collaborative study on the genetics of alcoholism: Brain function.Genes, brain, and behavior · 2023Review
- Genome-wide association studies: utility and limitations for research in physiology.The Journal of physiology · 2023Article
- A multivariate approach to investigate the associations of electrophysiological indices with schizophrenia clinical and functional outcome.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- The foundation and architecture of precision medicine in neurology and psychiatry.Trends in neurosciences · 2023Review
- Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning.Molecular psychiatry · 2022Article
- Genetic polymorphisms iniScience · 2022Article
- Genetics and Brain Transcriptomics of Completed Suicide.The American journal of psychiatry · 2022Article
- A scoping review of electroencephalographic (EEG) markers for tracking neurophysiological changes and predicting outcomes in substance use disorder treatment.Frontiers in human neuroscience · 2022Article
- The Enhancing NeuroImaging Genetics through Meta-Analysis Consortium: 10 Years of Global Collaborations in Human Brain Mapping.Human brain mapping · 2022Article
- What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group.Human brain mapping · 2022Review
Corrections and comments
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Authors and funding
22 authors at 7 institutions in 3 countries.
Dirk J A SmitPsychiatry department, Amsterdam Neuroscience, Academic Medical Center, University of Amsterdam, The Netherlands.ORCID 0000-0001-8301-8860
Margaret J WrightQueensland Brain Institute, University of Queensland, Brisbane, Australia.
Jacquelyn L MeyersHenri Begleiter Neurodynamics Lab., Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, New York.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Yvonne Y W HoQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Stephen M MaloneDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota.
Jian ZhangHenri Begleiter Neurodynamics Lab., Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, New York.
Scott J BurwellDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota.
David B ChorlianHenri Begleiter Neurodynamics Lab., Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, New York.
Eco J C de GeusBiological Psychology, Amsterdam Public Health research institute, Vrije Universiteit Amsterdam, The Netherlands.
Damiaan DenysPsychiatry department, Amsterdam Neuroscience, Academic Medical Center, University of Amsterdam, The Netherlands.
Narelle K HansellQueensland Brain Institute, University of Queensland, Brisbane, Australia.
Jouke-Jan HottengaBiological Psychology, Amsterdam Public Health research institute, Vrije Universiteit Amsterdam, The Netherlands.
Matt McGueDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota.
Catharina E M van BeijsterveldtBiological Psychology, Amsterdam Public Health research institute, Vrije Universiteit Amsterdam, The Netherlands.
Neda JahanshadImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Marina del Rey, California.
Paul M ThompsonImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Marina del Rey, California.
Christopher D WhelanImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Marina del Rey, California.
Sarah E MedlandQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Bernice PorjeszHenri Begleiter Neurodynamics Lab., Department of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, New York.
William G LaconoDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota.
Dorret I BoomsmaBiological Psychology, Amsterdam Public Health research institute, Vrije Universiteit Amsterdam, The Netherlands.
State University of New York · USUniversity of Minnesota · USVrije Universiteit Amsterdam · NLQIMR Berghofer Medical Research Institute · AUUniversity of Southern California · USAmsterdam UMC Location University of Amsterdam · NLThe University of Queensland · AU
Funding
NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8MSubject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MSubstance Abuse & Behavioral Disinhibition: Integrating Genes & EnvironmentU01DA024417 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2007 to 2010
$10.8MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MTWIN STUDY OF FEMALE ALCOHOLISMS AND OTHER DISORDERSR01AA009367 · NIAAA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCGUE, MATTHEW K. · 1992 to 2013
$9.0MIntegration of Genomics & Transcriptomics in Normal Twins & Major DepressionRC2MH089951 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2009 to 2010
$6.5MTwin Family Study of Vulnerability to Substance AbuseR37DA005147 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2009 to 2018
$6.4MTWIN/FAMILY STUDY OF VULNERABILITY TO SUBSTANCE ABUSER01DA005147 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI IACONO, WILLIAM G · 1987 to 2007
$5.5MAdolescent drinking and midlife outcomes: A prospective cotwin control studyR37AA009367 · NIAAA · UNIVERSITY OF MINNESOTA · PI MCGUE, MATTHEW K. · 2016 to 2024
$5.4MTWIN STUDY OF ADHD, CD, AND SUBSTANCE ABUSER01DA013240 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI IACONO, WILLIAM G. · 2000 to 2010
$5.0MGenomics of Developmental Trajectories in TwinsRC2MH089995 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUDZIAK, JAMES J. · 2009 to 2010
$3.8MNHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004438NHLBI NIH HHS HHSN268200782096CNIAAA NIH HHS R01 AA009367NIAAA NIH HHS R37 AA009367NIAAA NIH HHS U10 AA008401NIBIB NIH HHS U54 EB020403NICHD NIH HHS R01 HD042157NIDA NIH HHS K01 DA037914NIDA NIH HHS R01 DA005147NIDA NIH HHS R01 DA013240NIDA NIH HHS R01 DA024417NIDA NIH HHS R01 DA036216NIDA NIH HHS R37 DA005147NIDA NIH HHS U01 DA024417NIDDK NIH HHS R01 DK092127NIMH NIH HHS R01 MH081802NIMH NIH HHS RC2 MH089951NIMH NIH HHS RC2 MH089995NIMH NIH HHS U01 MH109528NIMH NIH HHS U24 MH068457
Abstract
Oscillatory activity is crucial for information processing in the brain, and has a long history as a biomarker for psychopathology. Variation in oscillatory activity is highly heritable, but current understanding of specific genetic influences remains limited. We performed the largest genome-wide association study to date of oscillatory power during eyes-closed resting electroencephalogram (EEG) across a range of frequencies (delta 1-3.75 Hz, theta 4-7.75 Hz, alpha 8-12.75 Hz, and beta 13-30 Hz) in 8,425 subjects. Additionally, we performed KGG positional gene-based analysis and brain-expression analyses. GABRA2-a known genetic marker for alcohol use disorder and epilepsy-significantly affected beta power, consistent with the known relation between GABA
Indexed as
ElectroencephalographyAdolescentAdultAgedBrainChildChild, PreschoolCohort StudiesFemaleGene ExpressionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMental DisordersMiddle Agedbrain expression pathwayelectroencephalography (EEG)endophenotypegenetic correlationGenome-Wide Association Study (GWAS)SNP heritability
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