Evidence map›Paper›PMID 29946991›Full record

ArticleMikrochimica acta2018

Hyaluronic acid-grafted three-dimensional MWCNT array as biosensing interface for chronocoulometric detection and fluorometric imaging of CD44-overexpressing cancer cells.

Minghuan Liu, Yanan Xu, Chusen Huang, Ti Jia, Xiaoyan Zhang, Da-Peng Yang, Nengqin Jia

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Article in Mikrochimica acta, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Minghuan LiuCollege of Chemical Engineering and Materials Science, Quanzhou Normal University, Quanzhou, 362000, Fujian Province, China.
Yanan XuThe Education Ministry Key Laboratory of Resource Chemistry Shanghai Key Laboratory of Rare Earth Functional Materials and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Department of Chemistry, Shanghai Normal University, Shanghai, 200234, China.
Chusen HuangThe Education Ministry Key Laboratory of Resource Chemistry Shanghai Key Laboratory of Rare Earth Functional Materials and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Department of Chemistry, Shanghai Normal University, Shanghai, 200234, China.
Ti JiaThe Education Ministry Key Laboratory of Resource Chemistry Shanghai Key Laboratory of Rare Earth Functional Materials and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Department of Chemistry, Shanghai Normal University, Shanghai, 200234, China.
Xiaoyan ZhangCollege of Chemical Engineering and Materials Science, Quanzhou Normal University, Quanzhou, 362000, Fujian Province, China.
Da-Peng YangCollege of Chemical Engineering and Materials Science, Quanzhou Normal University, Quanzhou, 362000, Fujian Province, China.
Nengqin JiaThe Education Ministry Key Laboratory of Resource Chemistry Shanghai Key Laboratory of Rare Earth Functional Materials and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Department of Chemistry, Shanghai Normal University, Shanghai, 200234, China. nqjia@shnu.edu.cn.
Shanghai Normal University · CNQuanzhou Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A sandwich-type electrochemical cytosensor is described for quantitative determination of CD44-overexpressing HeLa cells. Hyaluronic acid (HA) acts as a targeting molecule that was in-situ incorporated into the sensor based on the use of an indium tin oxide (ITO) electrode modified with multi-walled carbon nanotubes (MWCNTs). The 3D-MWCNT structure is shown to strongly improve the electronic properties and surface chemical reactivities. The HA-modified sensor exhibits a highly sensitive response to HeLa cells. A sandwiched hybridization protocol was then established using BIO [an N-butyl-4-(6'-aminohexyl)amino-1,8-naphthalimide probe modified with HA] as the tracing labels of the fluorescent probes for targeting CD44-positive tumor cells. The signal amplification was thereby maximized and measured by chronocoulometry. The binding of CD44-positive HeLa cells to the HA modified sensing layer causes a decrease in chronocoulometric response. The signal decreases linearly in the 2.1 × 10

Indexed as

Gene Expression Regulation, NeoplasticBiosensing TechniquesCell Line, TumorColorimetryHumansHyaluronan ReceptorsHyaluronic AcidLimit of DetectionNanotubes, CarbonOptical ImagingHyaluronan ReceptorsHyaluronic AcidNanotubes, CarbonChronocoulometryFluorescence labelingHeLa cellsHyaluronic acidNon-enzymatic sensor

Identifiers

PMID29946991
OpenAlexW2811104460

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.