ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2018
Targeted-Plasticity in the Corticospinal Tract After Human Spinal Cord Injury.
Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 46 citations in OpenAlex.
- Repeated transspinal stimulation decreases soleus H-reflex excitability and restores spinal inhibition in human spinal cord injury.PloS one · 2019Trial
- rTMS-induced motor cortex activation drives neural network tissueoid mediated spinal motor neural pathway reconstruction.Theranostics · 2026Article
- Paired corticospinal-motoneuronal stimulation enhances ballistic motor learning and corticospinal plasticity in older adults.The Journal of physiology · 2026Article
- Operant Conditioning of the Motor Evoked Potential in Forearm Extensors of Individuals with Chronic Incomplete Cervical Spinal Cord Injury: Case Studies.Topics in spinal cord injury rehabilitation · 2026Article
- Plasticity reloaded: motor skill learning plus stimulation boosts adaptations in the ageing nervous system.The Journal of physiology · 2026Article
- Microstructural integrity within the damaged region of the residual corticofugal projection from primary motor cortex predicts the effect of noninvasive neuromodulation targeting the spinal cord in chronic stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- The diversity and plasticity of descending motor pathways rewired after stroke and trauma in rodents.Frontiers in neural circuits · 2025Review
- Hebbian priming of human motor learning.Nature communications · 2024Article
- Home-based arm cycling exercise improves trunk control in persons with incomplete spinal cord injury: an observational study.Scientific reports · 2023Observational
- Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Increased paired stimuli enhance corticospinal-motoneuronal plasticity in humans with spinal cord injury.Journal of neurophysiology · 2023Article
- Transcranial magnetic stimulation-based closed-loop modality for activity of daily living gain in spinal cord injury: a retrospective study using propensity score matching analysis.European journal of physical and rehabilitation medicine · 2023Observational
- Neurophysiological Evaluation of Neural Transmission in Brachial Plexus Motor Fibers with the Use of Magnetic versus Electrical Stimuli.Sensors (Basel, Switzerland) · 2023Article
- Differences in sensorimotor and functional recovery between the dominant and non-dominant upper extremity following cervical spinal cord injury.Spinal cord · 2022Article
- Combined neuromuscular electrical stimulation and transcutaneous spinal direct current stimulation increases motor cortical plasticity in healthy humans.Frontiers in neuroscience · 2022Article
- Assessment of Corticospinal Excitability in Awake Rodents Using EMG-Controlled Intracortical Stimulation.Bio-protocol · 2021Article
- Combination of Stem Cells and Rehabilitation Therapies for Ischemic Stroke.Biomolecules · 2021Review
- A Time-Course Study of the Expression Level of Synaptic Plasticity-Associated Genes in Un-Lesioned Spinal Cord and Brain Areas in a Rat Model of Spinal Cord Injury: A Bioinformatic Approach.International journal of molecular sciences · 2021Article
- Comparison of systemic and localized carrier-mediated delivery of methylprednisolone succinate for treatment of acute spinal cord injury.Experimental brain research · 2021Article
- Prospects for intelligent rehabilitation techniques to treat motor dysfunction.Neural regeneration research · 2021Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Spinal cord injury (SCI) often results in impaired or absent sensorimotor function below the level of the lesion. Recent electrophysiological studies in humans with chronic incomplete SCI demonstrate that voluntary motor output can be to some extent potentiated by noninvasive stimulation that targets the corticospinal tract. We discuss emerging approaches that use transcranial magnetic stimulation (TMS) over the primary motor cortex and electrical stimulation over a peripheral nerve as tools to induce plasticity in residual corticospinal projections. A single TMS pulse over the primary motor cortex has been paired with peripheral nerve electrical stimulation at precise interstimulus intervals to reinforce corticospinal synaptic transmission using principles of spike-timing dependent plasticity. Pairs of TMS pulses have also been used at interstimulus intervals that mimic the periodicity of descending indirect (I) waves volleys in the corticospinal tract. This data, along with information about the extent of the injury, provides a new framework for exploring the contribution of the corticospinal tract to recovery of function following SCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.