Evidence map›Paper›PMID 29946971›Full record

Trial reportAnnals of biomedical engineering2018

Short-Term Contact Kinematic Changes and Longer-Term Biochemical Changes in the Cartilage After ACL Reconstruction: A Pilot Study.

Guoan Li, Jing-Sheng Li, Martin Torriani, Ali Hosseini

Abstract readClinical Trial
In one paragraph

Trial report in Annals of biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Guoan LiOrthopaedic Bioengineering Research Center, Newton-Wellesley Hospital and Harvard Medical School, Newton, MA, 02462, USA. gli1@partners.org.
Jing-Sheng LiOrthopaedic Bioengineering Research Center, Newton-Wellesley Hospital and Harvard Medical School, Newton, MA, 02462, USA.
Martin TorrianiDivision of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02215, USA.
Ali HosseiniOrthopaedic Bioengineering Research Center, Newton-Wellesley Hospital and Harvard Medical School, Newton, MA, 02462, USA.
Harvard University · USNewton Wellesley Hospital · US

Funding

In vivo ACL Reconstruction BiomechanicsR01AR055612 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI LI, GUOAN · 2008 to 2012
$1.9M
In-Vivo Ligamentous Tension of the KneeR21AR051078 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI LI, GUOAN · 2006 to 2007
$418k
National Institute of Arthritis and Musculoskeletal and Skin Diseases R01 AR055612NIAMS NIH HHS R01 AR055612NIAMS NIH HHS R21 AR051078
6 · The paper itself

Abstract

Investigation of the development of cartilage degeneration after ACL reconstruction is important for improving current surgical treatment of ACL injuries to prevent long-term knee joint degeneration. This pilot study examined the relationship between the changes in weight-bearing knee contact kinematics 6 months after ACL reconstruction and the biochemical composition changes in the knee cartilage measured using T2 relaxation values 3 years after the surgery in seven patients. The analysis indicated that the change of the knee contact kinematics in short-term after ACL reconstruction is associated with an increase of T2 values of the cartilage in longer follow up times. The data of this study could provide preliminary data to power future studies that use prospective, longitudinal research and large patient populations to establish prognostic biomechanical markers for determination of long-term cartilage degeneration after ACL reconstruction.

Indexed as

Cartilage, ArticularKnee InjuriesPlastic Surgery ProceduresAdultBiomechanical PhenomenaFemaleFollow-Up StudiesHumansKnee JointMalePilot ProjectsACLACL reconstructionCartilage degenerationKinematicsKneePrognostic marker

Identifiers

PMID29946971
PMCPMC6204103
OpenAlexW2811371597

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.