Evidence map›Paper›PMID 29946953›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2018

The Cost of Complications Following Major Resection of Malignant Neoplasia.

Cheryl K Zogg, Taylor D Ottesen, Kareem J Kebaish, Anoop Galivanche, Shilpa Murthy, Navin R Changoor, Donald L Zogg, Timothy M Pawlik, Adil H Haider

Abstract readComparative Study
In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Robotic versus open pancreaticoduodenectomy in octogenarians: a comparative propensity score analysis of perioperative outcomes.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2025
    Article
  5. Article
  6. COST-EFFECTIVENESS OF THE USE OF ACERTO PROTOCOL IN MAJOR DIGESTIVE SURGERY.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2022
    Article
  7. Article
  8. Quality Versus Costs Related to Gastrointestinal Surgery: Disentangling the Value Proposition.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020
    Review
  9. Observational
  10. Risk reduction in kidney surgery.Annals of translational medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cheryl K ZoggYale School of Medicine, 67 Cedar Street, Room 316 ESH, New Haven, CT, 06520, USA. czogg@jhmi.edu.ORCID 0000-0003-4461-746X
Taylor D OttesenYale School of Medicine, 67 Cedar Street, Room 316 ESH, New Haven, CT, 06520, USA.
Kareem J KebaishYale School of Medicine, 67 Cedar Street, Room 316 ESH, New Haven, CT, 06520, USA.
Anoop GalivancheYale School of Medicine, 67 Cedar Street, Room 316 ESH, New Haven, CT, 06520, USA.
Shilpa MurthyCenter for Surgery and Public Health, Harvard Medical School and Harvard T.H. Chan School of Public Health, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.
Navin R ChangoorCenter for Surgery and Public Health, Harvard Medical School and Harvard T.H. Chan School of Public Health, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.
Donald L ZoggMinnesota Gastroenterology, P.A., Saint Paul, MN, USA.
Timothy M PawlikDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Adil H HaiderCenter for Surgery and Public Health, Harvard Medical School and Harvard T.H. Chan School of Public Health, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

backgroundRising healthcare costs have led to increased focus on the need to achieve a higher "value of care." As value-maximization efforts expand to include more complex surgical patients, evidence to support meaningful implementation of complication-based initiatives is lacking. The objective of this study was to compare incremental costs of complications following major gastrointestinal (GI) resections for organ-specific malignant neoplasia using nationally representative data.

methodsNational (Nationwide) Inpatient Sample data, 2001-2014, were queried for adult (≥ 18 years) patients undergoing major resections for malignant neoplasia. Based on system-based complications considered relevant to the long-term treatment of GI disease, stratified differences in risk-adjusted incremental hospital costs and complication probabilities were compared. Differences in surgical outcomes and costs over time were also assessed.

resultsA total of 293,967 patients were included, weighted to represent 1,408,117 patients nationwide. One fourth (26.1%; 95% CI, 25.7-26.4%) experienced ≥ 1 pre-discharge complication (range, 45.3% esophagectomy to 24.0% rectal resection). Resultant annual risk-adjusted incremental hospital costs totaled $540 million nationwide (19.5% of the overall cost of care and an average of $20,900 per patient). Costs varied substantially with both cancer/resection type and complication group, ranging from $76.7 million for colectomies with infectious complications to $0.2 million for rectal resections with urinary complications. For each resection type, infectious ($154.7 million), GI ($85.5 million), and pulmonary ($77.9 million) complications were among the most significant drivers of increased hospital cost.

conclusionsQuantifying and comparing the impact of complications on an indication-specific level in more complex patients offers an important step toward allowing providers/payers to meaningfully prioritize the design of novel and adaptation of existing value-maximization approaches.

Indexed as

AdolescentAdultAgedAged, 80 and overDatabases, FactualDigestive System NeoplasmsDigestive System Surgical ProceduresFemaleGastrointestinal DiseasesHospital CostsHumansInfectionsLung DiseasesMaleMiddle AgedPostoperative ComplicationsCancerComplicationCostInfectionOncologyQualityValue

Identifiers

PMID29946953
PMCPMC6224301

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.