ArticleEnvironmental science and pollution research international2018
Combined effects of co-exposure to formaldehyde and acrolein mixtures on cytotoxicity and genotoxicity in vitro.
Article in Environmental science and pollution research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
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- Evaluation of the Effects of E-Cigarette Aerosol Extracts and Tobacco Cigarette Smoke Extracts on Human Gingival Epithelial Cells.ACS omega · 2023Article
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- A Hydrothermal Method to Generate Carbon Quantum Dots from Waste Bones and Their Detection of Laundry Powder.Molecules (Basel, Switzerland) · 2022Article
- Determination of Carbonyl Compounds in Different Work Environments: Comparison between LC-UV/DAD and LC-MS/MS Detection Methods.International journal of environmental research and public health · 2022Article
- Acrolein inhalation acutely affects the regulation of mitochondrial metabolism in rat lung.Toxicology · 2022Article
- Comparative Genotoxicity and Mutagenicity of Cigarette, Cigarillo, and Shisha Tobacco Products in Epithelial and Cardiac Cells.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Glutathione is a potential therapeutic target for acrolein toxicity in the cornea.Toxicology letters · 2021Article
- Acrolein exerts a genotoxic effect in the Leydig cells by stimulating DNA damage-induced apoptosis.Environmental science and pollution research international · 2020Article
- Ameliorative effect of boric acid against formaldehyde-induced oxidative stress in A549 cell lines.Environmental science and pollution research international · 2020Article
- Harmful chemicals emitted from electronic cigarettes and potential deleterious effects in the oral cavity.Tobacco induced diseases · 2020Review
- Efficient removal of gaseous formaldehyde by amine-modified diatomite: a combined experimental and density functional theory study.Environmental science and pollution research international · 2019Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
FA (formaldehyde) and ACR (acrolein) are common pollutants in environment, which often occur together in air. So, adverse health effects may not only result from their individual toxicity but also from the combined toxicity. While often studied alone, combination effects of these pollutants are inconclusive. Here, we examined the combined cytotoxicity and genotoxicity of FA and ACR on A549 cells based on CCK-8 assay, comet assay, and cytokinesis-block micronuclei assay. FA and ACR mixtures showed significant cytotoxicity and genotoxicity even at NOECs (no observed effect concentrations). Moreover, FA and ACR administrated jointly at doses from NOECs to sub-cytotoxic concentrations demonstrated significant interactions in cytotoxicity, DNA strand breaks, and chromosome damage. Co-exposure to FA and ACR significantly showed a lower responses on DNA strand break and chromosome damage than those expected for additivity, while an opposite result was obtained on cytotoxicity. Taken together, these results indicated that there was significant interactions on cytotoxicity and genotoxicity for FA and ACR, and prolonged exposure to mixtures of FA and ACR below sub-cytotoxic concentrations can produce a serious threat in human's health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.