ArticleInternational urogynecology journal2018
The urinary microbiome in patients with refractory urge incontinence and recurrent urinary tract infection.
Article in International urogynecology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Study of Microbiome of the Female Genital Area in Relation to Pelvic Floor Dysfunction: A Systematic Review.International urogynecology journal · 2024Pooled it
- Genomic relatedness and clinical significance ofMicrobial genomics · 2021Trial
- Urinary cytokines in women with refractory detrusor overactivity: A longitudinal study of rotating antibiotic versus placebo treatment.PloS one · 2021Trial
- Characterizing the role of the urobiome in the pathogenesis of recurrent urinary tract infections (rUTIs): a systematic review.International urology and nephrology · 2026Review
- Cystitis in guinea pigs (Cavia porcellus): Clinical findings and treatment outcomes.The Veterinary record · 2026Article
- Characterization and comparative analysis of urinary bacterial microbiome profiling in healthy cats and cats with feline idiopathic cystitis.Scientific reports · 2026Article
- Cervical Infection as a Novel Risk Factor for Perineal Obstetrical Trauma: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- A Cross Sectional Study of Cytokines in Women with Refractory Detrusor Overactivity versus Controls.International urogynecology journal · 2025Article
- High-riskeLife · 2024Article
- Urinary Microbiome in Bladder Diseases-Review.Biomedicines · 2023Review
- Article
- Cataloging variation in 16S rRNA gene sequences of female urobiome bacteria.Frontiers in urology · 2023Article
- The Urobiome and Its Role in Overactive Bladder.International neurourology journal · 2022Article
- Virulence Mechanisms of Common Uropathogens and Their Intracellular Localisation within Urothelial Cells.Pathogens (Basel, Switzerland) · 2022Article
- Gut-bladder axis in recurrent UTI.Nature microbiology · 2022Article
- Effects of a Supplement Containing a Cranberry Extract on Recurrent Urinary Tract Infections and Intestinal Microbiota: A Prospective, Uncontrolled Exploratory Study.Journal of integrative and complementary medicine · 2022Article
- Urethral failure is a critical factor in female urinary incontinence. Now what?Neurourology and urodynamics · 2022Article
- Urinary Tract Infection in Overactive Bladder: An Update on Pathophysiological Mechanisms.Frontiers in physiology · 2022Review
- The Vaginal Microbiome: III. The Vaginal Microbiome in Various Urogenital Disorders.Journal of lower genital tract disease · 2022Article
- [Urinary bladder microbiome analysis and probiotic treatment options for women with recurrent urinary tract infections].Der Urologe. Ausg. A · 2022Review
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Abstract
introduction and hypothesisUrinary urge incontinence is a chronic, debilitating condition that is difficult to treat. Patients refractory to standard antimuscarinic therapy often experience recurrent urinary tract infections (rUTIs). The microbiota of these refractory patients with rUTI remains unexplored.
methodsA midstream urine (MSU) sample was collected from patients with refractory urge incontinence and coexistent rUTI during acute symptomatic episodes. Culture-based diagnosis was performed using routine microbiological methods. Culture-independent profiling was performed using bacterial 16S RNA profiling. E. coli strain typing was performed by amplicon pyrosequencing of the fimH gene.
resultsOver 2 years, 39 patients with refractory urge incontinence and coexistent rUTI were studied, yielding 9 severely affected cases. These 9 patients were carefully monitored for a further 2 years, resulting in the collection of 102 MSU samples, 70 of which were diagnosed as UTI (median of 8 UTIs/woman). Culture-independent analysis of 38 of these samples revealed the existence of a diverse urinary microbiota. Strain typing of E. coli identified instances of rUTI caused by the same persisting strain and by new infecting strains.
conclusionsPatients with refractory urge incontinence and coexistent rUTI possess a diverse urinary microbiota, suggesting that persistent bladder colonisation might augment the pathology of their chronic condition.
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