Evidence map›Paper›PMID 29946374›Full record

ArticleClinical epigenetics2018

rs10732516 polymorphism at the

Heidi Marjonen, Pauliina Auvinen, Hanna Kahila, Olga Tšuiko, Sulev Kõks, Airi Tiirats, Triin Viltrop, Timo Tuuri, Viveca Söderström-Anttila, Anne-Maria Suikkari and 3 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Cryopreservation, cryoprotectants, and potential risk of epigenetic alteration.Journal of assisted reproduction and genetics · 2024
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Imprinting disorders in humans: a review.Current opinion in pediatrics · 2020
    Review
  10. Article
  11. Review
  12. Epigenetics and Neurological Disorders in ART.International journal of molecular sciences · 2019
    Review
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Heidi Marjonen1Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
Pauliina Auvinen1Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.
Hanna Kahila2Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Olga Tšuiko3Department of Biomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Sulev Kõks5Department of Pathophysiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Airi Tiirats7Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Triin Viltrop3Department of Biomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Timo Tuuri2Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Viveca Söderström-Anttila2Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Anne-Maria Suikkari9The Family Federation of Finland, Fertility Clinic, Helsinki, Finland.
Andres Salumets2Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Aila Tiitinen2Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Nina Kaminen-Ahola1Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-1255-4716
University of Helsinki · FICompetence Centre on Health Technologies (Estonia) · EEEstonian University of Life Sciences · EETartu University Hospital · EEUniversity of Tartu · EEVäestöliitto · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Assisted reproductive technology (ART) has been associated with low birth weight of fresh embryo transfer (FRESH) derived and increased birth weight of frozen embryo transfer (FET)-derived newborns. Owing to that, we focused on imprinted insulin-like growth factor 2 ( Results: A consistent trend of genotype-specific decreased methylation level was observed in paternal allele of rs10732516 paternal A/maternal G genotype, but not in paternal G/maternal A genotype, at Conclusions: The observed DNA methylation changes together with the phenotypic findings suggest that rs10732516 polymorphism associates with the effects of ART in a parent-of-origin manner. Therefore, this polymorphism should be considered when the effects of environmental factors on embryonic development are studied.

Indexed as

DNA MethylationGenomic ImprintingPolymorphism, Single NucleotideAdultBinding SitesBirth WeightCase-Control StudiesCCCTC-Binding FactorEstoniaFemaleFinlandGenotypeHumansInfant, NewbornInsulin-Like Growth Factor IIMaleCCCTC-Binding FactorCTCF protein, humanH19 long non-coding RNAIGF2 protein, humanInsulin-Like Growth Factor IIRNA, Long NoncodingAssisted reproductive technologyBirth weightDNA methylationFresh embryo transferFrozen embryo transferIGF2/H19ImprintingIVFPlacentars10732516

Identifiers

PMID29946374
PMCPMC6006593
OpenAlexW2808422384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.