ArticleNutrition & metabolism2018
GLUT1 and lactose synthetase are critical genes for lactose synthesis in lactating sows.
Article in Nutrition & metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Effects of hypoxia stress on the milk synthesis in bovine mammary epithelial cells.Journal of animal science and biotechnology · 2025Article
- The Selenium Yeast vs Selenium Methionine on Cell Viability, Selenoprotein Profile and Redox StatusFrontiers in veterinary science · 2022Article
- A Comparative Review of the Cell Biology, Biochemistry, and Genetics of Lactose Synthesis.Journal of mammary gland biology and neoplasia · 2021Review
- Artemisinin Protects Porcine Mammary Epithelial Cells against Lipopolysaccharide-Induced Inflammatory Injury by Regulating the NF-κB and MAPK Signaling Pathways.Animals : an open access journal from MDPI · 2021Article
- Effects of Selenomethionine on Cell Viability, Selenoprotein Expression and Antioxidant Function in Porcine Mammary Epithelial Cells.Frontiers in nutrition · 2021Article
- Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing.Cell reports · 2020Article
- Polyherbal formula (ASILACT®) induces Milk production in lactating rats through Upregulation of α-Lactalbumin and aquaporin expression.BMC complementary medicine and therapies · 2020Article
- Recent progress of porcine milk components and mammary gland function.Journal of animal science and biotechnology · 2018Review
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Authors and funding
7 authors.
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Abstract
backgroundLactose synthesis rate is an important factor in milk production and quality in mammals. Understanding the lactose synthesis mechanism is crucial for the improvement of milk quantity and quality. However, research on the temporal gene changes regarding lactose synthesis during the whole lactation is still limited. The objective of this study was to determine gene expression profiles related to lactose synthesis in sows during lactation, and further identify the critical steps or key factors in the lactose synthesis pathway.
methodsTo determine the temporal change of factors related to lactose synthesis in sows, milk from eight multiparous Yorkshire sows (parity 3 to 6) was collected at 0 h, 2 h, 6 h, 12 h, 24 h, day 2, 3, 4, 7, 14, and 21 after birth of the first piglet. Lactose content, prolactin and progesterone concentration, and gene or protein expression related to lactose synthesis were measured.
resultsThe lactose yield increased gradually from D2 to D21 and reached a maximum at D14 (3-fold from D2) during lactation (
conclusionsThese novel findings suggest that the increased lactose synthesis in lactation was related to the coordinated upregulation of genes or enzymes in the lactose synthesis pathway, and glucose transportation (GLUT1) and lactose synthetase (LALBA and B4GALT1) might be the critical steps in the lactose synthesis pathway of sows during lactation.
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