Evidence map›Paper›PMID 29946317›Full record

ArticleFrontiers in immunology2018

The C-Type Lectin Receptor DC-SIGN Has an Anti-Inflammatory Role in Human M(IL-4) Macrophages in Response to

Geanncarlo Lugo-Villarino, Anthony Troegeler, Luciana Balboa, Claire Lastrucci, Carine Duval, Ingrid Mercier, Alan Bénard, Florence Capilla, Talal Al Saati, Renaud Poincloux and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

  1. Pooled it
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  3. HowVaccines · 2026
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  5. Tissue signatures of human macrophages during homeostasis and activation.Journal of immunology (Baltimore, Md. : 1950) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 6 countries.

Geanncarlo Lugo-VillarinoInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Anthony TroegelerInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Luciana BalboaInternational Associated Laboratory (LIA) CNRS "IM-TB/HIV" (1167), Toulouse, France.
Claire LastrucciInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Carine DuvalInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Ingrid MercierInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Alan BénardInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Florence CapillaINSERM/UPS/US006 CREFRE, CHU Purpan, Toulouse, France.
Talal Al SaatiINSERM/UPS/US006 CREFRE, CHU Purpan, Toulouse, France.
Renaud PoinclouxInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Ivanela KondovaBiomedical Primate Research Centre, Rijswijk, Netherlands.
Frank A W VerreckBiomedical Primate Research Centre, Rijswijk, Netherlands.
Céline CougouleInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Isabelle Maridonneau-PariniInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Maria Del Carmen SasiainInternational Associated Laboratory (LIA) CNRS "IM-TB/HIV" (1167), Toulouse, France.
Olivier NeyrollesInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Centre National de la Recherche Scientifique · FRUniversité Toulouse III - Paul Sabatier · FRBiomedical Primate Research Centre · NLInstitut de Pharmacologie et de Biologie Structurale · FRAcademia Nacional de Medicina · ARInserm · FRUniversité Fédérale de Toulouse Midi-Pyrénées · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DC-SIGN (CD209/CLEC4L) is a C-type lectin receptor (CLR) that serves as a reliable cell-surface marker of interleukin 4 (IL-4)-activated human macrophages [M(IL-4)], which historically represent the most studied subset within the M2 spectrum of macrophage activation. Although DC-SIGN plays important roles in

Indexed as

AnimalsCell Adhesion MoleculesCell SurvivalCytokinesDC-Specific ICAM-3 Grabbing NonintegrinDectin-1FemaleGene ExpressionHost-Pathogen InteractionsHumansInflammation MediatorsLectins, C-TypeMacaca mulattaMacrophagesMonocytesMycobacterium tuberculosisCell Adhesion MoleculesCytokinesDC-Specific ICAM-3 Grabbing NonintegrinDectin-1Inflammation MediatorsLectins, C-TypeReceptors, Cell Surfaceanti-inflammatoryC-type lectin receptorsDC-SIGNmacrophagesMycobacterium tuberculosis

Identifiers

PMID29946317
PMCPMC6006465
OpenAlexW2803039915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.