Evidence map›Paper›PMID 29946296›Full record

ArticleFrontiers in endocrinology2018

Increased Concentrations of Insulin-Like Growth Factor Binding Protein (IGFBP)-2, IGFBP-3, and IGFBP-4 Are Associated With Fetal Mortality in Pregnant Cows.

Kirsten Mense, Julia Heidekorn-Dettmer, Elisa Wirthgen, Yette Brockelmann, Ralf Bortfeldt, Sarah Peter, Markus Jung, Christine Höflich, Andreas Hoeflich, Marion Schmicke

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Kirsten MenseInstitute for the Reproduction of Farm Animals Schoenow, Bernau, Germany.
Julia Heidekorn-DettmerClinic for Cattle, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
Elisa WirthgenInstitute of Genome Biology, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany.
Yette BrockelmannClinic for Cattle, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
Ralf BortfeldtInstitute for the Reproduction of Farm Animals Schoenow, Bernau, Germany.
Sarah PeterInstitute for the Reproduction of Farm Animals Schoenow, Bernau, Germany.
Markus JungInstitute for the Reproduction of Farm Animals Schoenow, Bernau, Germany.
Christine HöflichLigandis UG, Gülzow-Prüzen, Germany.
Andreas HoeflichInstitute of Genome Biology, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany.
Marion SchmickeClinic for Cattle, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
University of Veterinary Medicine Hannover, Foundation · DEResearch Institute for Farm Animal Biology (FBN) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insulin-like growth factors (IGFs) play a critical role in fetal growth, and components of the IGF system have been associated with fetal growth restriction in women. In human pregnancy, the proteolytic cleavage of insulin-like growth factor binding proteins (IGFBPs), particularly IGFBP-4, releases free IGF for respective action at the tissue level. The aim of the present study was to determine IGFBP-2, IGFBP-3, and IGFBP-4 concentrations by Western ligand blotting during pregnancy until day 100 in cows and to compare these concentrations with those of non-pregnant cows and cows undergoing embryonic/fetal mortality. Therefore, two study trials (I and II) and an

Indexed as

binding proteinbovineembryonic mortalitygestationIGF-1pregnancy

Identifiers

PMID29946296
PMCPMC6006986
OpenAlexW2803849424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.