ArticleThe ISME journal2018
Ixodes scapularis does not harbor a stable midgut microbiome.
Article in The ISME journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
71 citing papers in PubMed, 150 citations in OpenAlex.
- Tick Microbiome and Its Role in Emerging Zoonotic Diseases and Transmissibility.Microorganisms · 2026Review
- Immune-mediated microbial interference governsiScience · 2026Article
- Rhipicephalus sanguineus s.l. ticks (Acari: Ixodidae) harbor non-divergent bacterial microbiomes in Arizona.Journal of medical entomology · 2026Article
- Spatiotemporal and tissue-specific dynamics of bacterial communities in adult femaleFrontiers in cellular and infection microbiology · 2026Article
- Infection-Mediated Shifts in the Microbial Communities of Deer-FedMicroorganisms · 2025Article
- A systematic review of the microbiome ofVeterinary world · 2025Review
- Alterations in the salivary gland microbiota ofZoological research · 2025Article
- Exploring the microbiomes of camel ticks to infer vector competence: insights from tissue-level symbiont-pathogen relationships.Scientific reports · 2025Article
- Genomic and Proteomic Analyses of Bacterial Communities ofMicroorganisms · 2025Article
- The Tick Microbiome: The "Other Bacterial Players" in Tick Biocontrol.Microorganisms · 2024Review
- Bacterial community of ticks (Acari: Ixodidae) and mammals from Arauca, Colombian Orinoquia.International journal for parasitology. Parasites and wildlife · 2024Article
- Metatranscriptomic investigation of singlemSystems · 2024Article
- Significant role of symbiotic bacteria in the blood digestion and reproduction ofISME communications · 2024Article
- The immune factors involved in the rapid clearance of bacteria from the midgut of the tickFrontiers in cellular and infection microbiology · 2024Article
- A metalloprotease secreted by an environmentally acquired gut bacterium hindersFrontiers in cellular and infection microbiology · 2024Article
- Variation of bacterial community assembly over developmental stages and midgut of Dermanyssus gallinae.Microbial ecology · 2023Article
- The genetic basis of variation in immune defense against Lysinibacillus fusiformis infection in Drosophila melanogaster.PLoS pathogens · 2023Article
- Microbiota perturbation by anti-microbiota vaccine reduces the colonization of Borrelia afzelii in Ixodes ricinus.Microbiome · 2023Article
- Multiomics Reveals Symbionts, Pathogens, and Tissue-Specific Microbiome of Blacklegged Ticks (Ixodes scapularis) from a Lyme Disease Hot Spot in Southeastern Ontario, Canada.Microbiology spectrum · 2023Article
- Entomopathogenic fungus treatment changes the gut bacterial diversity of Rhipicephalus microplus ticks.Parasites & vectors · 2023Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
Hard ticks of the order Ixodidae serve as vectors for numerous human pathogens, including the causative agent of Lyme Disease Borrelia burgdorferi. Tick-associated microbes can influence pathogen colonization, offering the potential to inhibit disease transmission through engineering of the tick microbiota. Here, we investigate whether B. burgdorferi encounters abundant bacteria within the midgut of wild adult Ixodes scapularis, its primary vector. Through the use of controlled sequencing methods and confocal microscopy, we find that the majority of field-collected adult I. scapularis harbor limited internal microbial communities that are dominated by endosymbionts. A minority of I. scapularis ticks harbor abundant midgut bacteria and lack B. burgdorferi. We find that the lack of a stable resident midgut microbiota is not restricted to I. scapularis since extension of our studies to I. pacificus, Amblyomma maculatum, and Dermacentor spp showed similar patterns. Finally, bioinformatic examination of the B. burgdorferi genome revealed the absence of genes encoding known interbacterial interaction pathways, a feature unique to the Borrelia genus within the phylum Spirochaetes. Our results suggest that reduced selective pressure from limited microbial populations within ticks may have facilitated the evolutionary loss of genes encoding interbacterial competition pathways from Borrelia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.