ArticleHypertension research : official journal of the Japanese Society of Hypertension2018
Increased plasma fatty acid binding protein 4 concentration at the first prenatal visit and its relevance to preeclampsia.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Fatty Acid Transporter CD36 Promotes Ox-LDL-Induced Senescence of Vascular Endothelial Cells in Preeclampsia.Journal of inflammation research · 2025Article
- Serum fatty acid binding protein 4 and Doppler of uterine artery ultrasound in the first trimester for the prediction of preeclampsia.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Observational
- Review
- Hyperandrogenism diminishes maternal-fetal fatty acid transport by increasing FABP4-mediated placental lipid accumulation†.Biology of reproduction · 2022Article
- Association of circulating saturated fatty acids with the risk of pregnancy-induced hypertension: a nested case-control study.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- From animal models to patients: the role of placental microRNAs, miR-210, miR-126, and miR-148a/152 in preeclampsia.Clinical science (London, England : 1979) · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preeclampsia affects 2-8% of all pregnancies, and it is associated with significant perinatal mortality and morbidities including preterm birth and small for gestational age. We examined whether plasma fatty acid binding protein 4 (FABP4) concentrations are associated with risk of later preeclampsia development. From March 2015 to May 2016, serum FABP4 was measured in 1486 women in early pregnancy. The relationship between the levels of FABP4 and preeclampsia were evaluated using univariate and multivariate regression analysis. The median plasma concentration of FABP4 at the first prenatal visit was significantly higher in women in whom preeclampsia developed later compared with those in whom it did not (P < 0.001). For each 1 unit increase in FABP4 plasma concentration, the unadjusted and adjusted risk of preeclampsia increased by 8% (odds ratio (OR): 1.08; 95% confidence interval [CI]: 1.05-1.12) and 4% (1.04; 95% CI: 1.02-1.07), respectively. The addition of FABP4 to established risk factors significantly improved net reclassification improvement. Increased FABP4 at the first prenatal visit of gestation independently predicted preeclampsia and significantly improved reclassification and discrimination. This information is important to guide public health efforts in preeclampsia prevention.
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Registered trials
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