Evidence map›Paper›PMID 29946149›Full record

ArticleScientific reports2018

Influence of the viscosity of healthy and diseased human mucins on the motility of Helicobacter pylori.

Clover Su, Médea Padra, Maira Alves Constantino, Sinan Sharba, Anders Thorell, Sara K Lindén, Rama Bansil

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Nanomechanical Hallmarks ofInternational journal of molecular sciences · 2021
    Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. TFF1 Induces Aggregation and Reduces Motility ofInternational journal of molecular sciences · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Clover SuBoston University, Materials Science and Engineering Division, Boston, 02446, USA.
Médea PadraUniversity of Gothenburg, Department of Medical Biochemistry and Cell Biology, Göteborg, 41390, Sweden.
Maira Alves ConstantinoBoston University, Physics Department, Boston, 02215, USA.ORCID 0000-0002-2927-2275
Sinan SharbaUniversity of Gothenburg, Department of Medical Biochemistry and Cell Biology, Göteborg, 41390, Sweden.
Anders ThorellKarolinska Institutet, Department for Clinical Science and Department of Surgery, Ersta Hospital, Stockholm, Sweden.
Sara K LindénUniversity of Gothenburg, Department of Medical Biochemistry and Cell Biology, Göteborg, 41390, Sweden.
Rama BansilBoston University, Materials Science and Engineering Division, Boston, 02446, USA. rb@bu.edu.ORCID 0000-0003-1311-1749
Boston University · USUniversity of Gothenburg · SEKarolinska Institutet · SE

Funding

Modeling gastric mucus layer physiologyR01GM131408 · NIGMS · UNIVERSITY OF UTAH · PI FOGELSON, AARON L · 2018 to 2021
$1.5M
NIGMS NIH HHS R01 GM131408
6 · The paper itself

Abstract

We present particle tracking microrheology results on human mucins, isolated from normal surface and gland mucosa and one tumor sample, and examine the motility of Helicobacter pylori in these mucins. At 1.5% concentration human mucin solutions are purely viscous, with viscosity η (gland mucin) > η (surface mucin) > η (tumor mucin). In the presence of motile H. pylori bacteria, particle diffusion is enhanced, with diffusivity D

Indexed as

Bacterial Physiological PhenomenaHelicobacter InfectionsHelicobacter pyloriHumansMucinsRheologyViscosityMucins

Identifiers

PMID29946149
PMCPMC6018794
OpenAlexW2809195805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.