ArticleEmerging microbes & infections2018
Comparative genomics of Campylobacter concisus: Analysis of clinical strains reveals genome diversity and pathogenic potential.
Article in Emerging microbes & infections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- Calibrated interdental brushing for the prevention of periodontal pathogens infection in young adults - a randomized controlled clinical trial.Scientific reports · 2019Trial
- Genomic association of Campylobacter concisus for colonization advantages and virulence in children and adolescents with inflammatory bowel disease.BMC microbiology · 2026Article
- Virulome over taxonomy: refining the driver-passenger model in colorectal carcinogenesis.Frontiers in cellular and infection microbiology · 2026Review
- Genetic Diversity ofMicroorganisms · 2025Article
- Preharvest Control ofMicroorganisms · 2025Review
- Identification of Novel Gene-Specific Markers for Differentiating Various PathogenicPathogens (Basel, Switzerland) · 2025Article
- Gut microbiota and their metabolites ameliorate acute and chronic colitis in mice via modulating Th17/Treg balance.Frontiers in microbiology · 2025Article
- Genetic characteristics and potential pathogenic agents inEmerging microbes & infections · 2024Article
- Capturing clinically relevantMicrobial genomics · 2024Article
- The effect of sex steroid hormones on the ecology ofBiofilm · 2023Article
- Investigation ofFrontiers in microbiology · 2023Article
- Pan-Genome Analysis of Campylobacter: Insights on the Genomic Diversity and Virulence Profile.Microbiology spectrum · 2022Article
- Article
- Insight into the Relationship between Oral Microbiota and the Inflammatory Bowel Disease.Microorganisms · 2022Review
- Immune-Mediated Aggravation of theInternational journal of molecular sciences · 2021Article
- Co-pathogens in Periodontitis and Inflammatory Bowel Disease.Frontiers in medicine · 2021Review
- Metagenomics analysis of the gut microbiome in healthy and bacterial pneumonia forest musk deer.Genes & genomics · 2021Article
- Analysis of completeMicrobial genomics · 2020Article
- Innovative application of nested PCR for detection ofJournal of oral microbiology · 2020Review
- Complete Genome Sequence of Massilia oculi sp. nov. CCUG 43427Current microbiology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, an increasing number of Campylobacter species have been associated with human gastrointestinal (GI) diseases including gastroenteritis, inflammatory bowel disease, and colorectal cancer. Campylobacter concisus, an oral commensal historically linked to gingivitis and periodontitis, has been increasingly detected in the lower GI tract. In the present study, we generated robust genome sequence data from C. concisus strains and undertook a comprehensive pangenome assessment to identify C. concisus virulence properties and to explain potential adaptations acquired while residing in specific ecological niche(s) of the GI tract. Genomes of 53 new C. concisus strains were sequenced, assembled, and annotated including 36 strains from gastroenteritis patients, 13 strains from Crohn's disease patients and four strains from colitis patients (three collagenous colitis and one lymphocytic colitis). When compared with previous published sequences, strains clustered into two main groups/genomospecies (GS) with phylogenetic clustering explained neither by disease phenotype nor sample location. Paired oral/faecal isolates, from the same patient, indicated that there are few genetic differences between oral and gut isolates which suggests that gut isolates most likely reflect oral strain relocation. Type IV and VI secretion systems genes, genes known to be important for pathogenicity in the Campylobacter genus, were present in the genomes assemblies, with 82% containing Type VI secretion system genes. Our findings indicate that C. concisus strains are genetically diverse, and the variability in bacterial secretion system content may play an important role in their virulence potential.
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