Evidence map›Paper›PMID 29946074›Full record

ArticleScientific reports2018

A sensitive electrochemical immunosensor for label-free detection of Zika-virus protein.

Ajeet Kaushik, Adriana Yndart, Sanjeev Kumar, Rahul Dev Jayant, Arti Vashist, Ashley N Brown, Chen-Zhong Li, Madhavan Nair

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Cell-Based Immuno-Biosensors Using Microfluidics.Sensors (Basel, Switzerland) · 2026
    Review
  4. Review
  5. Article
  6. Biosensors for the detection of flaviviruses: A review.Synthetic and systems biotechnology · 2025
    Review
  7. Article
  8. Signal-Amplified Nanobiosensors for Virus Detection Using Advanced Nanomaterials.Advances in biochemical engineering/biotechnology · 2024
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Nanomaterials-based sensors for the detection of COVID-19: A review.Bioengineering & translational medicine · 2022
    Review
  15. Article
  16. Review
  17. Review
  18. Virus Detection: From State-of-the-Art Laboratories to Smartphone-Based Point-of-Care Testing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Review
  19. Review
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ajeet KaushikCenter of Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, 33199, USA. ajeet.npl@gmail.com.
Adriana YndartCenter of Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, 33199, USA.
Sanjeev KumarBiomedical Instrumentation, CSIR-Central Scientific Instruments Organization, Sector 30-C, Chandigarh, 160030, India.
Rahul Dev JayantCenter of Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, 33199, USA.ORCID 0000-0002-2584-3878
Arti VashistCenter of Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, 33199, USA.
Ashley N BrownInstitute for Therapeutic Innovation, Department of Medicine, College of Medicine, University of Florida, Orlando, Florida, 32827, USA.
Chen-Zhong LiNanobioengineering/Bioelectronics Laboratory, Department of Biomedical Engineering, Florida International University, 10555 West Flagler Street, Miami, Florida, 33174, USA.
Madhavan NairCenter of Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, 33199, USA. naimm@fiu.edu.

Funding

Florida Department of Health FDOH-7ZK09Florida International University (FIU) 800008106
6 · The paper itself

Abstract

This work, as a proof of principle, presents a sensitive and selective electrochemical immunosensor for Zika-virus (ZIKV)-protein detection using a functionalized interdigitated micro-electrode of gold (IDE-Au) array. A miniaturized IDE-Au immunosensing chip was prepared via immobilization of ZIKV specific envelop protein antibody (Zev-Abs) onto dithiobis(succinimidyl propionate) i.e., (DTSP) functionalized IDE-Au (electrode gap/width of 10 µm). Electrochemical impedance spectroscopy (EIS) was performed to measure the electrical response of developed sensing chip as a function of ZIKV-protein concentrations. The results of EIS studies confirmed that sensing chip detected ZIKV-protein selectively and exhibited a detection range from 10 pM to 1 nM and a detection limit of 10 pM along with a high sensitivity of 12 kΩM

Indexed as

Biosensing TechniquesDielectric SpectroscopyElectrochemical TechniquesViral ProteinsZika VirusViral Proteins

Identifiers

PMID29946074
PMCPMC6018776

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.