ArticleNature communications2018
An effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervals.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Methamphetamine-induced adaptation of learning rate dynamics depend on baseline performance.eLife · 2025Trial
- Neuromorphic Devices and Computing for Sensing, Memory, and Control.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Serotonergic modulation of motor subspace dynamics drives a sleep-independent quiescent state.eLife · 2026Article
- Building Goal-Directed Cognitive Graphs.bioRxiv : the preprint server for biology · 2026Article
- HMM for discovering decision-making dynamics using reinforcement learning experiments.Biostatistics (Oxford, England) · 2025Article
- JOINT MODELING FOR LEARNING DECISION-MAKING DYNAMICS IN BEHAVIORAL EXPERIMENTS.The annals of applied statistics · 2025Article
- Asymmetric learning and adaptability to changes in relational structure during transitive inference.Communications psychology · 2025Article
- Attentional switching in larval zebrafish.Science advances · 2025Article
- Article
- Optogenetic Stimulation of Novel Tph2-Cre Rats Advances Insight into Serotonin's Role in Locomotion, Reinforcement, and Compulsivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Acetylcholine modulates prefrontal outcome coding during threat learning under uncertainty.eLife · 2025Article
- Complementary roles of serotonin and dopamine in model-based learning.Current opinion in behavioral sciences · 2025Article
- Computational and Neural Evidence for Altered Fast and Slow Learning from Losses in Problem Gambling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dopamine transients encode reward prediction errors independent of learning rates.Cell reports · 2024Article
- Investigating Transfer Learning in Noisy Environments: A Study of Predecessor and Successor Features in Spatial Learning Using a T-Maze.Sensors (Basel, Switzerland) · 2024Article
- Monoaminergic Modulation of Learning and Cognitive Function in the Prefrontal Cortex.Brain sciences · 2024Review
- Dopamine transients encode reward prediction errors independent of learning rates.bioRxiv : the preprint server for biology · 2024Article
- 5-HT 2A and 5-HT 2C receptor antagonism differentially modulate reinforcement learning and cognitive flexibility: behavioural and computational evidence.Psychopharmacology · 2024Article
- Optogenetic activation of dorsal raphe serotonin neurons induces brain-wide activation.Nature communications · 2024Article
- Active reinforcement learning versus action bias and hysteresis: control with a mixture of experts and nonexperts.PLoS computational biology · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Serotonin has widespread, but computationally obscure, modulatory effects on learning and cognition. Here, we studied the impact of optogenetic stimulation of dorsal raphe serotonin neurons in mice performing a non-stationary, reward-driven decision-making task. Animals showed two distinct choice strategies. Choices after short inter-trial-intervals (ITIs) depended only on the last trial outcome and followed a win-stay-lose-switch pattern. In contrast, choices after long ITIs reflected outcome history over multiple trials, as described by reinforcement learning models. We found that optogenetic stimulation during a trial significantly boosted the rate of learning that occurred due to the outcome of that trial, but these effects were only exhibited on choices after long ITIs. This suggests that serotonin neurons modulate reinforcement learning rates, and that this influence is masked by alternate, unaffected, decision mechanisms. These results provide insight into the role of serotonin in treating psychiatric disorders, particularly its modulation of neural plasticity and learning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.