Evidence map›Paper›PMID 29946066›Full record

ArticleThe Journal of antibiotics2018

Macrolide and phenolic metabolites from the marine-derived fungus Paraconiothyrium sp. VK-13 with anti-inflammatory activity.

Tran Hong Quang, Dong Cheol Kim, Phan Van Kiem, Chau Van Minh, Nguyen Xuan Nhiem, Bui Huu Tai, Pham Hai Yen, Nguyen Thi Thanh Ngan, Hye Jin Kim, Hyuncheol Oh

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of antibiotics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Secondary Metabolites from FungiJournal of fungi (Basel, Switzerland) · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Tran Hong QuangInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Dong Cheol KimCollege of Pharmacy, Wonkwang University, Iksan, 54538, Republic of Korea.
Phan Van KiemInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam. phankiem@yahoo.com.
Chau Van MinhInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Nguyen Xuan NhiemInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Bui Huu TaiInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Pham Hai YenInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Nguyen Thi Thanh NganInstitute of Genome Research, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Hye Jin KimCollege of Pharmacy, Wonkwang University, Iksan, 54538, Republic of Korea.
Hyuncheol OhCollege of Pharmacy, Wonkwang University, Iksan, 54538, Republic of Korea. hoh@wku.ac.kr.
Vietnam Academy of Science and Technology · VNWonkwang University · KR

Funding

National Research Foundation of Korea (NRF) 016K2A9A1A06924074 PY2016National Research Foundation of Korea (NRF) NRF-2017R1A5A2015805
6 · The paper itself

Abstract

Five new secondary metabolites, modiolides D-G (1-4) and 1-(2,5-dihydroxyphenyl)-3-methoxy-butan-1-one (8), one new natural product, 1-(2,5-dihydroxyphenyl)-3-hydroxybutan-1-one (7), along with three known compounds, modiolides A (5) and B (6), and 1-(2,5-dihydroxyphenyl)-2-buten-1-one (9) were isolated from a fermentation culture of the marine endophytic fungus Paraconiothyrium sp. VK-13. Their chemical structures were elucidated by the NMR and MS spectroscopic analysis as well as the modified Mosher's method. Compounds 7 and 9 inhibited the overproduction of proinflammatory mediators NO and PGE

Indexed as

AnimalsAnti-Inflammatory AgentsAscomycotaCell LineDinoprostoneMacrolidesMiceNitric OxideNitric Oxide Synthase Type IIRAW 264.7 CellsSecondary MetabolismAnti-Inflammatory AgentsDinoprostoneMacrolidesmodiolide Amodiolide BNitric OxideNitric Oxide Synthase Type IINos2 protein, mouse

Identifiers

PMID29946066
OpenAlexW2810056994

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.