Evidence map›Paper›PMID 29946039›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Endogenous Protection from Ischemic Brain Injury by Preconditioned Monocytes.

Lidia Garcia-Bonilla, David Brea, Corinne Benakis, Diane A Lane, Michelle Murphy, Jamie Moore, Gianfranco Racchumi, Xinran Jiang, Costantino Iadecola, Josef Anrather

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Monocyte-derived macrophages and their roles in ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Neuroprotective effect of ischemic postconditioning against hyperperfusion and its mechanisms of neuroprotection.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024
    Review
  15. Frontiers in cellular neuroscience · 2024
    Article
  16. Article
  17. Article
  18. Review
  19. Monocyte regulation by gut microbial signals.Trends in microbiology · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lidia Garcia-BonillaFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York 10065.
David BreaFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York 10065.
Corinne BenakisFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York 10065.
Diane A LaneFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York 10065.
Michelle MurphyFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York 10065.
Jamie MooreFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York 10065.
Gianfranco RacchumiFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York 10065.
Xinran JiangFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York 10065.
Costantino IadecolaFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York 10065.
Josef AnratherFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York 10065 joa2006@med.cornell.edu.
Cornell University · USMIND Research Institute · USWeill Cornell Medicine · US

Funding

NO SYNTHASE GENE EXPRESSION AND CEREBRAL ISCHEMIC DAMAGER01NS034179 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 1995 to 2021
$5.5M
Protective monocytes in cerebral ischemic toleranceR01NS081179 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ANRATHER, JOSEF · 2012 to 2022
$3.7M
NO SYNTHASE GENE EXPRESSION AND CEREBRAL ISCHEMIC DAMAGER37NS034179 · NINDS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 1999 to 2005
$1.8M
NINDS NIH HHS R01 NS034179NINDS NIH HHS R01 NS081179NINDS NIH HHS R37 NS034179
6 · The paper itself

Abstract

Exposure to low-dose lipopolysaccharide (LPS) before cerebral ischemia is neuroprotective in stroke models, a phenomenon termed preconditioning (PC). Although it is well established that LPS-PC induces central and peripheral immune responses, the cellular mechanisms modulating ischemic injury remain unclear. Here, we investigated the role of immune cells in the brain protection afforded by PC and tested whether monocytes may be reprogrammed by

Indexed as

MonocytesStrokeAdoptive TransferAnimalsBrain IschemiaHumansIschemic PreconditioningLipopolysaccharidesMaleMiceMice, Inbred C57BLNeuroprotectionLipopolysaccharidesadoptive transfercerebral ischemialipopolysaccharidemonocytesneuroprotection

Identifiers

PMID29946039
PMCPMC6067076
OpenAlexW2952294166

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.