ArticleProceedings of the National Academy of Sciences of the United States of America2018
Action potential counting at giant mossy fiber terminals gates information transfer in the hippocampus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- In vivo magnetic recording of neuronal action potentials using a differential TMR magnetrode.Microsystems & nanoengineering · 2026Article
- Dendritic Inhibition Terminates Plateau Potentials in CA1 Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Synaptic plasticity in the perforant pathway drives inhibitory reorganization enhancing dentate gyrus functionality.iScience · 2026Article
- Distinct Patterns of Evoked Firing in Engram and Non-Engram Neurons in the Dentate Gyrus of Hippocampal Slices.Hippocampus · 2025Article
- Fiber-basedNeurophotonics · 2024Article
- How Merkel cells transduce mechanical stimuli: A biophysical model of Merkel cells.PLoS computational biology · 2023Article
- The release of inhibition model reproduces kinetics and plasticity of neurotransmitter release in central synapses.Communications biology · 2023Article
- Enhanced excitability but mature action potential waveforms at mossy fiber terminals of young, adult-born hippocampal neurons in mice.Communications biology · 2023Article
- Article
- Asynchronous glutamate release is enhanced in low release efficacy synapses and dispersed across the active zone.Nature communications · 2022Article
- A biophysical counting mechanism for keeping time.Biological cybernetics · 2022Review
- cAMP-Dependent Synaptic Plasticity at the Hippocampal Mossy Fiber Terminal.Frontiers in synaptic neuroscience · 2022Review
- Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits.PLoS computational biology · 2021Article
- Article
- Linear-nonlinear cascades capture synaptic dynamics.PLoS computational biology · 2021Article
- Slow-decaying presynaptic calcium dynamics gate long-lasting asynchronous release at the hippocampal mossy fiber to CA3 pyramidal cell synapse.Synapse (New York, N.Y.) · 2020Article
- Article
- A two-compartment model of synaptic computation and plasticity.Molecular brain · 2020Review
- A neuromechanistic model for rhythmic beat generation.PLoS computational biology · 2019Article
- The subthreshold-active KCommunications biology · 2019Article
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Authors and funding
5 authors.
Funding
Abstract
Neuronal communication relies on action potential discharge, with the frequency and the temporal precision of action potentials encoding information. Hippocampal mossy fibers have long been recognized as conditional detonators owing to prominent short-term facilitation of glutamate release displayed during granule cell burst firing. However, the spiking patterns required to trigger action potential firing in CA3 pyramidal neurons remain poorly understood. Here, we show that glutamate release from mossy fiber terminals triggers action potential firing of the target CA3 pyramidal neurons independently of the average granule cell burst frequency, a phenomenon we term action potential counting. We find that action potential counting in mossy fibers gates glutamate release over a broad physiological range of frequencies and action potential numbers. Using rapid Ca
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