Evidence map›Paper›PMID 29946007›Full record

Trial reportThe European respiratory journal2018

Stability or improvement in forced vital capacity with nintedanib in patients with idiopathic pulmonary fibrosis.

Kevin R Flaherty, Martin Kolb, Carlo Vancheri, Wenbo Tang, Craig S Conoscenti, Luca Richeldi

Abstract readClinical Trial, Phase IIIRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in The European respiratory journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. The use of chest magnetic resonance imaging in interstitial lung disease: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2018
    Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Advancing Drug Development in Idiopathic Pulmonary Fibrosis: Tomorrow Is Now.American journal of respiratory and critical care medicine · 2024
    Article
  9. Review
  10. Article
  11. Observational
  12. Article
  13. Review
  14. Review
  15. Observational
  16. Article
  17. Article
  18. Article
  19. Management of Idiopathic Pulmonary Fibrosis.The Annals of pharmacotherapy · 2019
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Kevin R FlahertyUniversity of Michigan Health System, Ann Arbor, MI, USA.
Martin KolbMcMaster University, Hamilton, ON, Canada.
Carlo VancheriDept of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Wenbo TangBoehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA.
Craig S ConoscentiBoehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA.
Luca RicheldiUniversità Cattolica del Sacro Cuore, Fondazione Policlinico A. Gemelli, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the Phase III INPULSIS® trials, nintedanib reduced the annual rate of decline in forced vital capacity (FVC)

Indexed as

AgedEnzyme InhibitorsFemaleFollow-Up StudiesHumansIdiopathic Pulmonary FibrosisIndolesLungMaleMiddle AgedSeverity of Illness IndexTreatment OutcomeVital CapacityWeight LossEnzyme InhibitorsIndolesnintedanib

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.