Evidence map›Paper›PMID 29946004›Full record

ArticleThe European respiratory journal2018

Anaerobic bacteria cultured from cystic fibrosis airways correlate to milder disease: a multisite study.

Marianne S Muhlebach, Joseph E Hatch, Gisli G Einarsson, Stef J McGrath, Deirdre F Gilipin, Gillian Lavelle, Bojana Mirkovic, Michelle A Murray, Paul McNally, Nathan Gotman and 7 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in The European respiratory journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 94 citations in OpenAlex.

  1. Establishment of anmSystems · 2026
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  2. Journal of bacteriology · 2026
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  6. Gingipain proteases from the bacteriumProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2026
    Article
  9. Article
  10. BioMed research international · 2026
    Review
  11. Article
  12. Genomic diversity inMicrobial genomics · 2025
    Article
  13. Article
  14. Article
  15. Frontiers in nutrition · 2025
    Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 3 countries.

Marianne S MuhlebachDept of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Joseph E HatchMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Gisli G EinarssonHalo Research Group, School of Pharmacy, Queen's University Belfast, Belfast, UK.
Stef J McGrathHalo Research Group, School of Pharmacy, Queen's University Belfast, Belfast, UK.
Deirdre F GilipinHalo Research Group, School of Pharmacy, Queen's University Belfast, Belfast, UK.
Gillian LavelleRespiratory Research Division, Dept of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.
Bojana MirkovicRespiratory Research Division, Dept of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.ORCID 0000-0002-2128-6779
Michelle A MurrayRespiratory Research Division, Dept of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.
Paul McNallyDept of Paediatrics, Royal College of Surgeons in Ireland, Our Lady's Children's Hospital Crumlin, Dublin, Ireland.ORCID 0000-0001-7102-1712
Nathan GotmanDept of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sonia Davis ThomasDept of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Matthew C WolfgangMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Peter H GilliganPathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Noel G McElvaneyRespiratory Research Division, Dept of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.
J Stuart ElbornHalo Research Group, Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Richard C BoucherMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Michael M TunneyHalo Research Group, School of Pharmacy, Queen's University Belfast, Belfast, UK.
University of North Carolina at Chapel Hill · USQueen's University Belfast · GBRoyal College of Surgeons in Ireland · IE

Funding

Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Richard Charles Boucher, Martina Gentzsch · 2004 to 2026
$26.5M
The Biophysics of Mucus Hydration and Adhesion/CohesionP01HL108808 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PEDEN, DAVID B. · 2012 to 2021
$23.9M
The Mucus Transport Apparatus: Why Two Layers?P50HL084934 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2006 to 2010
$15.6M
The Role of Anaerobic Bacterial Infection in Cystic FibrosisR01HL092964 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2010 to 2013
$2.9M
The lung microbiota in cystic fibrosisRC1HL100809 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LI, JUN, LIPUMA, JOHN J · 2009 to 2010
$999k
Medical Research CouncilNHLBI NIH HHS P01 HL108808NHLBI NIH HHS P50 HL084934NHLBI NIH HHS R01 HL092964NHLBI NIH HHS RC1 HL100809NIDDK NIH HHS P30 DK065988
6 · The paper itself

Abstract

Anaerobic and aerobic bacteria were quantitated in respiratory samples across three cystic fibrosis (CF) centres using extended culture methods. Subjects aged 1-69 years who were clinically stable provided sputum (n=200) or bronchoalveolar lavage (n=55). 18 anaerobic and 39 aerobic genera were cultured from 59% and 95% of samples, respectively; 16 out of 57 genera had a ≥5% prevalence across centres.Analyses of microbial communities using co-occurrence networks in sputum samples showed groupings of oral, including anaerobic, bacteria, whereas typical CF pathogens formed distinct entities.

Indexed as

AdolescentAdultAgedAnti-Bacterial AgentsBacteria, AnaerobicBacterial InfectionsChildChild, PreschoolCystic FibrosisFemaleHumansInfantInternationalityLogistic ModelsMaleMicrobiotaAnti-Bacterial Agents

Identifiers

PMID29946004
PMCPMC6376871
OpenAlexW2810931978

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.