Evidence map›Paper›PMID 29945985›Full record

ReviewDevelopment (Cambridge, England)2018

What does time mean in development?

Miki Ebisuya, James Briscoe

Abstract readReview
In one paragraph

Review in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed.

  1. Article
  2. Heterotypic intercellular adhesion tunes efficiency of cell-on-cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. NADThe EMBO journal · 2026
    Article
  4. Article
  5. Desynchrony between events triggers a compensatory delay duringbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Review
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  12. Review
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  17. Article
  18. Review
  19. Review
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Miki EbisuyaRIKEN Center for Biosystems Dynamics Research (RIKEN BDR), 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, 650-0047, Japan miki.ebisuya@riken.jp james.briscoe@crick.ac.uk.ORCID 0000-0003-1854-7496
James BriscoeThe Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK miki.ebisuya@riken.jp james.briscoe@crick.ac.uk.ORCID 0000-0002-1020-5240

Funding

Cancer Research UK FC001051Wellcome Trust FC001051
6 · The paper itself

Abstract

Biology is dynamic. Timescales range from frenetic sub-second ion fluxes and enzymatic reactions to the glacial millions of years of evolutionary change. Falling somewhere in the middle of this range are the processes we usually study in development: cell division and differentiation, gene expression, cell-cell signalling, and morphogenesis. But what sets the tempo and manages the order of developmental events? Are the order and tempo different between species? How is the sequence of multiple events coordinated? Here, we discuss the importance of time for developing embryos, highlighting the necessity for global as well as cell-autonomous control. New reagents and tools in imaging and genomic engineering, combined with

Indexed as

Embryonic DevelopmentAnimalsGene Expression Regulation, DevelopmentalModels, BiologicalSpecies SpecificityTime Factors

Identifiers

PMID29945985
PMCPMC6031406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.