ArticleG3 (Bethesda, Md.)2018
On the Relationship Between High-Order Linkage Disequilibrium and Epistasis.
Article in G3 (Bethesda, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Phantom epistasis through the lens of genealogies.Genetics · 2026Article
- Untargeted and targeted metabolomics approaches to characterise, select and advance cassava pre-breeding populations with enhanced whitefly tolerance.The Plant journal : for cell and molecular biology · 2025Article
- Article
- cLD: Rare-variant linkage disequilibrium between genomic regions identifies novel genomic interactions.PLoS genetics · 2023Article
- GWLD: an R package for genome-wide linkage disequilibrium analysis.G3 (Bethesda, Md.) · 2023Article
- Missing Causality and Heritability of Autoimmune Hepatitis.Digestive diseases and sciences · 2023Article
- Article
- Quinoa genome assembly employing genomic variation for guided scaffolding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- The Role of SNP Interactions when Determining Independence of Novel Signals in Genetic Association Studies-An Application toJournal of personalized medicine · 2021Article
- Phantom Epistasis in Genomic Selection: On the Predictive Ability of Epistatic Models.G3 (Bethesda, Md.) · 2020Article
- The Impact of Non-additive Effects on the Genetic Correlation Between Populations.G3 (Bethesda, Md.) · 2020Article
- Gene-Environment Interaction in the Era of Precision Medicine - Filling the Potholes Rather Than Starting to Build a New Road.Frontiers in genetics · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A plausible explanation for statistical epistasis revealed in genome wide association analyses is the presence of high order linkage disequilibrium (LD) between the genotyped markers tested for interactions and unobserved functional polymorphisms. Based on findings in experimental data, it has been suggested that high order LD might be a common explanation for statistical epistasis inferred between local polymorphisms in the same genomic region. Here, we empirically evaluate how prevalent high order LD is between local, as well as distal, polymorphisms in the genome. This could provide insights into whether we should account for this when interpreting results from genome wide scans for statistical epistasis. An extensive and strong genome wide high order LD was revealed between pairs of markers on the high density 250k SNP-chip and individual markers revealed by whole genome sequencing in the
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.