Observational studyJournal of the American Heart Association2018
Increased Left Ventricular Mass Index Is Associated With Compromised White Matter Microstructure Among Older Adults.
Observational study in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Left Ventricular Hypertrophy and Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.Journal of stroke · 2020Pooled it
- High-Sensitivity Troponin T, NT-proBNP, and Cognitive Outcomes in SPRINT.Hypertension (Dallas, Tex. : 1979) · 2024Trial
- Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Relations of left ventricular mass and hypertrophy to cognitive function in urban dwelling African American and White adults.Neuropsychology · 2026Article
- Association of total cerebral small vessel disease burden with left ventricular hypertrophy and geometry in patients with ischemic stroke.Frontiers in neuroscience · 2026Article
- Genetic insights into the mediating role of cardiac function in hypertension-induced brain cortical changes: a Mendelian randomization study with cardiac magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2025Article
- The effect of Alzheimer's disease genetic factors on limbic white matter microstructure.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Volumetric brain MRI signatures of heart failure with preserved ejection fraction in the setting of dementia.Magnetic resonance imaging · 2024Article
- Empirical assessment of the assumptions of ComBat with diffusion tensor imaging.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Septal E/e' Ratio Is Associated With Cerebral White Matter Hyperintensity Progression in Young-Old Hypertensive Patients.Circulation reports · 2023Article
- Multi-organ imaging demonstrates the heart-brain-liver axis in UK Biobank participants.Nature communications · 2022Article
- Brain and cardiovascular-related changes are associated with aging, hypertension, and atrial fibrillation.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Review
- Axonal Injury Partially Mediates Associations Between Increased Left Ventricular Mass Index and White Matter Damage.Stroke · 2022Observational
- Cardiac Hypertrophy Is Associated With Advanced Brain Aging in the General Population.Journal of the American Heart Association · 2021Article
- Impaired Frontal Brain Activity in Patients With Heart Failure Assessed by Near-Infrared Spectroscopy.Journal of the American Heart Association · 2020Article
- Echocardiographic index E/e' in association with cerebral white matter hyperintensity progression.PloS one · 2020Article
- Increased Left Ventricular Mass Index Is Associated With Compromised White Matter Microstructure Among Older Adults.Journal of the American Heart Association · 2018Observational
- Cerebrospinal fluid YKL-40 relates to white matter hyperintensity progression in females but not males over a 6-year period.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLeft ventricular (LV) hypertrophy is associated with cerebrovascular disease and cognitive decline. Increased LV mass index is a subclinical imaging marker that precedes overt LV hypertrophy. This study relates LV mass index to white matter microstructure and cognition among older adults with normal cognition and mild cognitive impairment. METHODS AND
resultsVanderbilt Memory & Aging Project participants free of clinical stroke, dementia, and heart failure (n=318, 73±7 years, 58% male, 39% mild cognitive impairment) underwent brain magnetic resonance imaging, cardiac magnetic resonance, and neuropsychological assessment. Voxelwise analyses related LV mass index (g/m
conclusionsIn the absence of prevalent heart failure and clinical stroke, increased LV mass index corresponds to altered white matter microstructure, particularly among older adults with clinical symptoms of prodromal dementia. Findings highlight the potential link between subclinical LV remodeling and cerebral white matter microstructure vulnerability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.