Evidence map›Paper›PMID 29945903›Full record

ArticleThe Journal of cell biology2018

Actin filaments partition primary cilia membranes into distinct fluid corrals.

Sungsu Lee, Han Yen Tan, Ivayla I Geneva, Aleksandr Kruglov, Peter D Calvert

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. A human-specificMolecular therapy. Nucleic acids · 2025
    Article
  3. Genetic interaction ofbioRxiv : the preprint server for biology · 2025
    Article
  4. Review
  5. Actin cytoskeletal regulation of ciliogenesis in development and disease.Developmental dynamics : an official publication of the American Association of Anatomists · 2024
    Review
  6. Evolutionary trajectory for nuclear functions of ciliary transport complex proteins.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  7. Article
  8. Article
  9. Review
  10. Scanning electron microscopy of human islet cilia.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Extracellular vesicle-mediated delivery of anti-miR-106b inhibits morphine-induced primary ciliogenesis in the brain.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
  12. Review
  13. Article
  14. Single-molecule imaging in the primary cilium.Methods in cell biology · 2023
    Article
  15. Shedding of ciliary vesicles at a glance.Journal of cell science · 2022
    Article
  16. Review
  17. Comparison of Ciliary Targeting of Two Rhodopsin-Like GPCRs: Role of C-Terminal Localization Sequences in Relation to Cilium Type.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  18. Functional compartmentalization of photoreceptor neurons.Pflugers Archiv : European journal of physiology · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sungsu LeeCenter for Vision Research and Department of Ophthalmology, State University of New York Upstate Medical University, Syracuse, NY.
Han Yen TanCenter for Vision Research and Department of Ophthalmology, State University of New York Upstate Medical University, Syracuse, NY.
Ivayla I GenevaCenter for Vision Research and Department of Ophthalmology, State University of New York Upstate Medical University, Syracuse, NY.
Aleksandr KruglovCenter for Vision Research and Department of Ophthalmology, State University of New York Upstate Medical University, Syracuse, NY.ORCID 0000-0002-7875-1029
Peter D CalvertCenter for Vision Research and Department of Ophthalmology, State University of New York Upstate Medical University, Syracuse, NY calvertp@upstate.edu.ORCID 0000-0001-9162-4924
SUNY Upstate Medical University · US

Funding

Supplement for ZetaSizer instrumentR01EY018421 · NEI · UPSTATE MEDICAL UNIVERSITY · PI CALVERT, PETER DEANE · 2007 to 2025
$6.2M
NEI NIH HHS R01 EY018421
6 · The paper itself

Abstract

Physical properties of primary cilia membranes in living cells were examined using two independent, high-spatiotemporal-resolution approaches: fast tracking of single quantum dot-labeled G protein-coupled receptors and a novel two-photon super-resolution fluorescence recovery after photobleaching of protein ensemble. Both approaches demonstrated the cilium membrane to be partitioned into corralled domains spanning 274 ± 20 nm, within which the receptors are transiently confined for 0.71 ± 0.09 s. The mean membrane diffusion coefficient within the corrals,

Indexed as

Actin CytoskeletonAnimalsCell LineCell MembraneCiliaMiceQuantum Dots

Identifiers

PMID29945903
PMCPMC6080922
OpenAlexW2811493968

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.