ArticleLipids in health and disease2018
Prospective plasma lipid profiling in individuals with and without depression.
Article in Lipids in health and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between atherogenic index of plasma and depression risk: a meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Trial
- Lower HDL-cholesterol, a known marker of cardiovascular risk, was associated with depression in type 1 diabetes: a cross sectional study.Lipids in health and disease · 2019Trial
- Evaluating the incremental value of an expanded cardiovascular health score for the prevalence of abdominal aortic calcification among middle-aged and elderly individuals.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- LDL-C modifies the association between triglycerides and depression identified by threshold scanning in US adults.Scientific reports · 2026Article
- Beyond inflammation and cholesterol: atherogenic index of plasma mediates the link between hsCRP/HDL-C ratio and depression in US adults NHANES 2015-2020.Annals of general psychiatry · 2026Article
- Machine Learning-Based Prediction of Antepartum Depression Symptoms: A Prospective Cohort Study.International journal of women's health · 2026Article
- Prevalence and associated factors of psychotic symptoms in young first-episode, drug-naïve major depressive disorder patients with abnormal lipid metabolism.European journal of medical research · 2025Article
- Towards Objective Major Depressive Disorder Detection: a Systematic Review and Meta-Analysis of Diagnostic Biomarkers.The Psychiatric quarterly · 2025Review
- Blood Plasma Lipid Alterations Differentiating Psychotic and Affective Disorder Patients.Biomolecules · 2025Article
- Metabolic Modulators in Depression: Emerging Molecular Mechanisms and Therapeutic Opportunities.International journal of molecular sciences · 2025Review
- Novel biomarkers of the Framingham risk score in patients with depression: A cross-sectional study.World journal of psychiatry · 2025Article
- Lipid metabolic dysregulation-induced neuroinflammation in the pathophysiology of major depressive disorder.Frontiers in immunology · 2025Review
- Thyroid dysfunction in elderly first-episode drug-naïve major depressive disorder patients with comorbid dyslipidemia: prevalence, clinical profile and associated factors.Frontiers in psychiatry · 2025Article
- Association between dyslipidemia and depression: a cross-sectional analysis of NHANES data from 2007 to 2018.BMC psychiatry · 2024Article
- The relationship between dyslipidemia and menopausal symptoms in Chinese menopausal women: a cross-sectional study.Archives of women's mental health · 2024Article
- Predictive Value of Life's Crucial 9 for Cardiovascular and All-Cause Mortality: A Prospective Cohort Study From the NHANES 2007 to 2018.Journal of the American Heart Association · 2024Article
- Prevalence and clinical correlates of abnormal lipid metabolism in older Chinese patients with first-episode drug-naïve major depressive disorder.BMC psychiatry · 2024Article
- Association between depression and infertility risk among American women aged 18-45 years: the mediating effect of the NHHR.Lipids in health and disease · 2024Article
- Examining the cross-sectional relationship of platelet/high-density lipoprotein cholesterol ratio with depressive symptoms in adults in the United States.BMC psychiatry · 2024Article
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6 authors.
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Abstract
backgroundSo far, studies on possible association of plasma lipid levels and depressive disorder are contradictory. This prospective work aimed at assessing a plasma lipid profile in individuals with major depression and healthy controls.
methodsIn total, 94 patients with major depression and 152 healthy controls were included in this prospective study. After an overnight fasting state of 12 h they underwent blood drawing for triglyzerides (TG), total cholesterol, low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol measurements. All participants were evaluated in a clinical interview and filled out the self-rating Beck Depression Inventory (BDI-II) scale to identify depressive symptomatology.
resultsNinety-four patients with major depression showed significantly higher median (interquartile range) plasma TG levels (108.0 [75.8-154.1] vs. 84.0 [63.0-132.2] mg/dL, P = 0.014) and significantly lower HDL-cholesterol levels (55.0 [46.9-123.0] vs. 61.5 [47.4-72.6] mg/dL, P = 0.049) compared to 152 individuals without depression, respectively. Total and LDL-cholesterol concentrations were observed slightly higher in patients with major depression. Significant positive correlation was found between TG, total cholesterol and LDL-cholesterol concentrations and the BDI-II score (p = 0.027, 0.048 and 0.018), and in tendency negative correlation between HDL-cholesterol levels and the BDI-II score (P = 0.091), respectively.
conclusionsDepressive individuals were found with adverse plasma lipid patterns of higher TG and lower HDL-cholesterol levels compared to healthy controls. On this basis, the authors would suggest the implementation of routine lipid measurements in order to stratify these patients by their cardiovascular risk.
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