Evidence map›Paper›PMID 29945463›Full record

ArticleCell transplantation2018

Calcium: A Crucial Potentiator for Efficient Enzyme Digestion of the Human Pancreas.

Torsten Eich, Magnus Ståhle, Bengt Gustafsson, Rune Horneland, Marko Lempinen, Torbjörn Lundgren, Ehab Rafael, Gunnar Tufveson, Bengt von Zur-Mühlen, Johan Olerud and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cell transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Torsten Eich1 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Magnus Ståhle1 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Bengt Gustafsson2 Department of Transplantation, Sahlgrenska University Hospital, Gothenburg, Sweden.
Rune Horneland3 Department of Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Marko Lempinen4 Department of Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland.
Torbjörn Lundgren5 Division of Transplantation Surgery, CLINTEC, Karolinska University Hospital, Stockholm, Sweden.
Ehab Rafael6 Transplantation Unit, Department of Surgery, Skåne University Hospital, Malmö, Sweden.
Gunnar Tufveson7 Department of Surgical Sciences, Division of Transplantation Surgery, Uppsala University Hospital, Uppsala, Sweden.
Bengt von Zur-Mühlen7 Department of Surgical Sciences, Division of Transplantation Surgery, Uppsala University Hospital, Uppsala, Sweden.
Johan Olerud1 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Hanne Scholz3 Department of Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Olle Korsgren1 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Uppsala University · SEOslo University Hospital · NOUppsala University Hospital · SEHelsinki University Hospital · FIKarolinska University Hospital · SESahlgrenska University Hospital · SESkåne University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEffective digestive enzymes are crucial for successful islet isolation. Supplemental proteases are essential because they synergize with collagenase for effective pancreatic digestion. The activity of these enzymes is critically dependent on the presence of Ca

methodsHuman islets were isolated according to standard methods and isolation parameters. Islet quality control and the number of isolations fulfilling standard transplantation criteria were evaluated. Ca

resultsCa

conclusionsCa

Indexed as

AdultAgedBicarbonatesCalciumCollagenasesDonor SelectionFemaleHumansHydrogen-Ion ConcentrationIslets of LangerhansIslets of Langerhans TransplantationMaleMiddle AgedPancreasPeptide HydrolasesQuality ControlBicarbonatesCalciumCollagenasesPeptide Hydrolasescalciumclinical islet transplantationdiabetesislet isolation

Identifiers

PMID29945463
PMCPMC6158545
OpenAlexW2810306332

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.