ArticlePsychiatry investigation2018
Electroconvulsive Seizure Alters the Expression and Daily Oscillation of Circadian Genes in the Rat Frontal Cortex.
Article in Psychiatry investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Circadian rhythms in the blood-brain barrier: impact on neurological disorders and stress responses.Molecular brain · 2023Review
- Brain-to-brain communication: the possible role of brain electromagnetic fields (As a Potential Hypothesis).Heliyon · 2021Review
- Review
- The Molecular Genetic Interaction Between Circadian Rhythms and Susceptibility to Seizures and Epilepsy.Frontiers in neurology · 2020Review
- Is Advancing Circadian Rhythm the Mechanism of Antidepressants?Psychiatry investigation · 2019Article
- Long-Term Changes in Self-Report Auditory Verbal Hallucinations in Patients with Schizophrenia Using Clozapine.Psychiatry investigation · 2019Article
- Is Advancing of Circadian Rhythm a Reason for the Rapid Treatment Effect of Electroconvulsive Therapy?Psychiatry investigation · 2018Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveElectroconvulsive therapy (ECT) is the most effective treatment for mood disorders. Accumulating evidence has suggested the important role of circadian genes in mood disorders. However, the effects of ECT on circadian genes have not been systemically investigated.
methodsWe examined the expression and daily oscillation of major circadian genes in the rat frontal cortex after electroconvulsive seizure (ECS).
resultsFirstly, mRNA and protein level were investigated at 24 hr after single ECS (E1X) and repeated ECS treatements for 10 days (E10X), which showed more remarkable changes after E10X than E1X. mRNA expression of Rorα, Bmal1, Clock, Per1, and Cry1 was decreased, while Rev-erbα expression was increased at 24 hr after E10X compared to sham. The proteins showed similar pattern of changes. Next, the effects on oscillation and rhythm properties (mesor, amplitude, and acrophase) were examined, which also showed more prominent changes after E10X than E1X. After E10X, mesor of Rorα, Bmal1, and Cry1 was reduced, and that of Rev-erbα was increased. Five genes, Rev-erbα, Bmal1, Per1, Per2, and Cry2, showed earlier acrophase after E10X.
conclusionThe findings suggest that repeated ECS induces reduced expression and phase advance of major circadian genes in the in vivo rat frontal cortex.
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