ArticleIntegrative and comparative biology2018
Mitochondrial Dysfunction and Infection Generate Immunity-Fecundity Tradeoffs in Drosophila.
Article in Integrative and comparative biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
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- A naturally occurring mitochondrial genome variant confers broad protection from infection in Drosophila.PLoS genetics · 2024Article
- Mitochondrial perturbation in immune cells enhances cell-mediated innate immunity in Drosophila.BMC biology · 2024Article
- Review
- Variation in mitochondrial DNA affects locomotor activity and sleep in Drosophila melanogaster.Heredity · 2022Article
- Review
- Integrating GWAS and Transcriptomics to Identify the Molecular Underpinnings of Thermal Stress Responses inFrontiers in genetics · 2020Article
- Midgut Mitochondrial Function as a Gatekeeper for Malaria Parasite Infection and Development in the Mosquito Host.Frontiers in cellular and infection microbiology · 2020Review
- Natural infection by the protozoan Leptomonas wallacei impacts the morphology, physiology, reproduction, and lifespan of the insect Oncopeltus fasciatus.Scientific reports · 2019Article
- Temperature-Sensitive Reproduction and the Physiological and Evolutionary Potential for Mother's Curse.Integrative and comparative biology · 2019Article
- Genetic Variation for Ontogenetic Shifts in Metabolism Underlies Physiological Homeostasis inGenetics · 2019Article
- Long-lived Temnothorax ant queens switch from investment in immunity to antioxidant production with age.Scientific reports · 2019Article
- Sexual Dimorphisms in Innate Immunity and Responses to Infection inFrontiers in immunology · 2019Review
- Age Dependent Dysfunction of Mitochondrial and ROS Metabolism Induced by Mitonuclear Mismatch.Frontiers in genetics · 2019Article
- Article
- The Mitochondrial Contribution to Animal Performance, Adaptation, and Life-History Variation.Integrative and comparative biology · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Physiological responses to short-term environmental stressors, such as infection, can have long-term consequences for fitness, particularly if the responses are inappropriate or nutrient resources are limited. Genetic variation affecting energy acquisition, storage, and usage can limit cellular energy availability and may influence resource-allocation tradeoffs even when environmental nutrients are plentiful. Here, we utilized Drosophila mitochondrial-nuclear genotypes to test whether disrupted mitochondrial function interferes with nutrient-sensing pathways, and whether this disruption has consequences for tradeoffs between immunity and fecundity. We found that an energetically-compromised genotype was relatively resistant to rapamycin-a drug that targets nutrient-sensing pathways and mimics resource limitation. Dietary resource limitation decreased survival of energetically-compromised flies. Furthermore, survival of infection with a natural pathogen was decreased in this genotype, and females of this genotype experienced immunity-fecundity tradeoffs that were not evident in genotypic controls with normal energy metabolism. Together, these results suggest that this genotype may have little excess energetic capacity and fewer cellular nutrients, even when environmental nutrients are not limiting. Genetic variation in energy metabolism may therefore act to limit the resources available for allocation to life-history traits in ways that generate tradeoffs even when environmental resources are not limiting.
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